Evidence map›Paper›PMID 41318542›Full record

ArticleBMC oral health2025

A possible correlation between periodontal disease and systemic diseases: a clinical study.

Saverio Ceraulo, Antonio Barbarisi, Gianluigi Caccianiga, Manuela Lodico, Francesca Cremonini, Dorina Lauritano, Francesco Carinci

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saverio CerauloDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza, 20100, Italy.
Antonio BarbarisiDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza, 20100, Italy. a.barbarisi@campus.unimib.it.
Gianluigi CaccianigaDepartment of Translational Medicine, University of Ferrara, Ferrara, 44121, Italy.
Manuela LodicoDepartment Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Francesca CremoniniDepartment of Translational Medicine, University of Ferrara, Ferrara, 44121, Italy.
Dorina LauritanoDepartment of Translational Medicine, University of Ferrara, Ferrara, 44121, Italy.
Francesco CarinciDepartment of Translational Medicine, University of Ferrara, Ferrara, 44121, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeriodontal disease (PD) is a widespread inflammatory condition with potential systemic implications. Its association with diseases such as diabetes, cardiovascular conditions, and hypovitaminosis D suggests a complex interplay involving immune-inflammatory mechanisms. To evaluate the correlation between PD and systemic biomarkers—blood glucose, glycated hemoglobin, cholesterol, vitamin D, and TSH, promoting awareness of the importance of regular health checkups.

methodsEighty patients underwent periodontal evaluation and blood testing. Statistical analysis was used to explore associations between PD and systemic alterations.

resultsPD was significantly associated with higher glycemia (p < 0.05), and linked to altered cholesterol and vitamin D levels, and increasing age. TSH levels showed a trend toward lower levels in PD patients, warranting further investigation.

conclusionsThis study supports a possible bidirectional relationship between PD and systemic health. Findings suggest PD may contribute to increased risk of conditions like diabetes and atherosclerosis. The observed link with systemic biomarkers highlights the need for integrated diagnostic and preventive strategies. Future research with larger, more diverse populations is essential to validate these associations and to explore the impact of treating systemic conditions on periodontal outcomes.

Indexed as

Periodontal DiseasesAdultBiomarkersBlood GlucoseCardiovascular DiseasesCholesterolFemaleGlycated HemoglobinHumansMaleMiddle AgedThyrotropinVitamin DBiomarkersBlood GlucoseCholesterolGlycated HemoglobinThyrotropinVitamin DCardiovascular diseaseDiabetes mellitusGlycated hemoglobinHigh-density lipoprotein cholesterolPeriodontal diseaseThyrotropinThyroxineTriiodothyronineVitamin d

Identifiers

PMID41318542
PMCPMC12771966

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.