Evidence map›Paper›PMID 41318500›Full record

Trial reportImplementation science : IS2025

A randomized trial of adapted versus standard versions the transdiagnostic intervention for sleep and circadian dysfunction (TSC) implemented via facilitation and delivered by community mental health providers using train-the-trainer.

Allison G Harvey, Emma R Agnew, Rafael Esteva Hache, Catherine A Callaway, Estephania Ovalle Patino, Anne Milner, Julia M Spencer, Marlen Diaz, Lu Dong, Amy M Kilbourne and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Implementation science : IS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05805657 (Implementing and Sustaining a Transdiagnostic Sleep and Circadian Treatment to Improve Severe Mental Illness Outcomes in Community Mental Health Part 2), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05805657 nacompletednot on this map

Implementing and Sustaining a Transdiagnostic Sleep and Circadian Treatment to Improve Severe Mental Illness Outcomes in Community Mental Health Part 2: Train-the-Trainer

TypeinterventionalSponsorUniversity of California, BerkeleyRan2020 to 2024Enrolled196ConditionsSleep Disorder, Circadian DysregulationArmsStandard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Usual Care Delayed Treatment
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Allison G HarveyDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA. aharvey@berkeley.edu.ORCID 0000-0002-8609-0005
Emma R AgnewDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA.
Rafael Esteva HacheDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA.
Catherine A CallawayDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA.
Estephania Ovalle PatinoDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA.
Anne MilnerDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA.
Julia M SpencerDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA.
Marlen DiazDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA.
Lu DongRAND Corporation, Santa Monica, CA, USA.
Amy M KilbourneOffice of Research and Development, Veterans Health Administration, U.S. Department of Veterans Affairs, Washington, MI, USA.
Daniel J BuysseUniversity of Pittsburgh, Pittsburgh, PA, USA.
Eric SticeStanford University, Stanford, CA, USA.
Laurel D SarfanDepartment of Psychology, University of California, 2121 Berkeley Way, Berkeley, CA, 94720, USA.

Funding

Implementing and Sustaining a Transdiagnostic Sleep and Circadian Treatment to Improve Severe Mental Illness Outcomes in Community Mental Health.R01MH120147 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARVEY, ALLISON G · 2019 to 2023
$3.9M
Advancing Sustainability of Evidence-Based Treatments in Community Mental HealthF32MH131284 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI SARFAN, LAUREL D · 2022 to 2024
$76k
NIMH NIH HHS F32 MH131284NIMH NIH HHS F32MH131284NIMH NIH HHS R01 MH120147NIMH NIH HHS R01MH120147
6 · The paper itself

Abstract

backgroundGrounded in the Integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework, we investigated the Train-the-Trainer (TTT) to expand access to evidence-based psychological treatments (EBPTs) in community mental health centers (CMHCs), focusing on the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TSC).

methodsEight Californian counties were cluster-randomized to Standard TSC or an adapted version designed to improve the "fit" of TSC to CMHCs. University-based trainers trained CMHC providers ("Generation 1 providers") in either Adapted or Standard TSC. These trained providers were then trained to become local CMHC trainers ("Generation 1 trainers"), who then trained a new cohort of providers ("Generation 2 providers") in TSC. Within each county, patients diagnosed with serious mental illness (SMI) were randomized to receive either immediate TSC or usual care and delayed treatment with TSC (UC-DT) from the Generation 2 providers ("Generation 2 patients"). This study focused on 53 Generation 2 providers (Adapted TSC = 47; Standard TSC = 6), and 143 Generation 2 patients (Adapted TSC = 127; Standard TSC = 16) (the larger Adapted sample was driven by recruitment, perhaps reflecting preference for the "fitted" approach). Patient assessments were conducted pre-treatment, post-treatment, and six-month follow-up (6FU). Provider assessments occurred after completing TSC training and post-treatment for each patient treated.

resultsCombining Adapted and Standard, TSC was associated with improvements for Generation 2 patients from pre- to post-treatment in sleep disturbance (p < 0.001, d = -0.90), sleep-related impairment (p = 0.001, d = -0.69), psychiatric symptoms (p = 0.002, d = -0.48), and functional impairment (p = 0.002, d = -0.54), relative to UC-DT. The effects of sleep disturbance and impairment on the relationship between treatment condition (TSC vs. UC-DT) and psychiatric symptoms and functional impairment were significant. Higher provider perception of TSC fit predicted improvements in selected patient outcomes.

conclusionTSC can be delivered by CMHC providers trained by local CMHC trainers with strong outcomes. These data contribute to the dearth of evidence for TTT collected from locally trained providers and from patients treated by local CMHC trainers.

trial registrationClinicaltrials.gov identifier: NCT05805657 . Registered on March 10, 2023.

Indexed as

Community Mental Health ServicesSleep Disorders, Circadian RhythmSleep Wake DisordersAdultCaliforniaCommunity Mental Health CentersFemaleHumansMaleMental DisordersMiddle AgedAdaptationAnxiety disorderBipolar disorderCircadianCommunity mental healthDepressionFacilitationInsomniaI-PARIHSMental illnessPsychosisSleepTrain-the-trainerTransdiagnostic

Identifiers

PMID41318500
PMCPMC12801857

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.