Trial reportNutrition journal2025
The cognitive effects of supplementation with sunflower phosphatidyl serine in healthy children aged 8 to 12 years: a randomized controlled trial.
Trial report in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05177978 (The Chronic Cognitive Effects of 6- and 12-weeks Administration of a Food Supplement Containing Phosphatidylserine), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Chronic Cognitive Effects of 6- and 12-weeks Administration of a Food Supplement Containing Phosphatidylserine: A Double Blind, Randomized, Placebo Controlled, Parallel Groups Study in Healthy Children Aged 8 to 12 Years
Who cites it
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSupplementation of the diet with phosphatidylserine (PS) is associated with cognitive and neuropsychological benefits in healthy and neuro-compromised adults. It has also been shown to mitigate symptoms of inattention in children with attention-deficit hyperactivity disorder. However, there is little data on the effects of PS in healthy children.
objectiveThe aim of this randomized, placebo-controlled clinical trial was to examine the effects of sunflower-derived PS on cognitive performance in healthy, neurotypical children aged 8-12 years.
methodsParticipants received 100 mg of sunflower-derived PS daily in gummy form or a matching placebo for 12 weeks and completed an assessment battery at baseline and after 6 and 12 weeks to monitor changes in cognitive performance, mood, and sleep. Retrospectively registered at Clinicaltrials.gov; NCT05177978
resultsThere were no differences in the primary or secondary outcomes in the total cohort. However, in a pre-defined subgroup analysis of children who were selected based on their constant below median performance across the cognitive tasks at baseline, PS-supplementation showed benefit on a visuospatial memory task. The supplementation with 100 mg of Sharp PS green was shown to be safe and well tolerated.
conclusionAlthough there were no differences in the primary and secondary outcomes, the findings suggest that future research should focus on children with below median performance, who are more prone to benefit from PS supplementation.
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