ArticleBMC oral health2025
The interrelationship between periodontitis and pancreatic cancer: a retrospective cohort study.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The association between periodontal disease and pancreatic cancer: epidemiology, mechanisms, and implications for clinical management.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontitis and pancreatic cancer are major public health concerns with increasing prevalence worldwide, including in Taiwan. Although previous studies have suggested a potential association between periodontitis and pancreatic cancer, findings remain inconclusive, particularly in Taiwanese populations. This study aimed to investigate the relationship between periodontitis and pancreatic cancer.
methodsThe study conducted a retrospective cohort study using data from Taiwan's National Health Insurance Research Database (NHIRD) between 2000 and 2019. Patients diagnosed with periodontitis were compared with matched controls without periodontitis. All statistical analyses were conducted using SAS software. Beyond descriptive statistics, the study conducted bivariate analyses to examine differences between patients with and without pancreatic cancer, followed by Cox regression to further evaluate the the risk of pancreatic cancer, adjusting for demographic, clinical, and socioeconomic factors.
resultsA total of 428,814 patients with periodontitis and matched controls were included. Overall, no significant increase in pancreatic cancer risk was observed among periodontitis patients compared with controls (aHR = 1.08, 95% CI: 0.96-1.22). However, subgroup analyses indicated higher risks in specific populations, including males (aHR = 1.16, 95% CI: 1.01-1.34), individuals aged 45-64 years (aHR = 4.43, 95% CI: 3.68-5.33), and those aged ≥ 65 years (aHR = 9.18, 95% CI: 7.43-11.30). Additionally, low annual expenditures for periodontitis care (≤ USD 11) and higher outpatient visit frequencies (> 0.7 per year) were associated with increased pancreatic cancer risk.
conclusionThe study findings underscore the potential role of periodontitis as a risk factor for pancreatic cancer in specific subgroups. Effective management of periodontitis, particularly among high-risk populations, may help mitigate systemic inflammatory effects linked to pancreatic cancer. Further studies are warranted to clarify the underlying mechanisms and inform targeted prevention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.