Trial reportBMC anesthesiology2025
Effects of remimazolam versus propofol on the optic nerve sheath diameter in patients undergoing laparoscopic hysterectomy: a randomized controlled trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have suggested that propofol can reduce intracranial pressure (ICP). However, the effects of remimazolam, a new intravenous anesthetic, on ICP remain unknown. This study aimed to compare the effects of remimazolam and propofol on the ICP in patients undergoing laparoscopic hysterectomy by measuring the optic nerve sheath diameter (ONSD) using ultrasound.
methodsA total of 60 patients scheduled for elective laparoscopic hysterectomy were randomly assigned to remimazolam group (0.3 mg/kg induction, 1-2 mg/kg/h infusion) and propofol group (2 mg/kg induction, 4-8 mg/kg/h infusion). The ONSD was measured 5 min after induction of anesthesia in the supine position (T1); 15 min (T2), 30 min (T3), and 60 min (T4) following the establishment of pneumoperitoneum and the Trendelenburg position; and at 5 min after desufflation in the supine position (T5). Respiratory and hemodynamic variables, postoperative nausea and vomiting, and headache were also recorded.
resultsCompared with the ONSD measured at T1, the ONSD at T2-T5 were significantly increase in both groups (P<0.05), whereas the extent of change in ONSD at T2-T5 showed no significant differences between the propofol group and remimazolam group (7.30% vs. 8.11%, 9.45% vs. 10.41%, 9.37% vs. 10.31%, 4.26% vs. 4.25%, P>0.05).
conclusionsThe extent of the increase in ONSD during the laparoscopic hysterectomy has no significantly difference between remimazolam and propofol anesthesia, suggesting that remimazolam and propofol may have similar effects on ICP.
trial registrationThis trial was retrospectively registered in the Chinese Clinical Trial Registry on April 18, 2025 (Registration Number: ChiCTR 2500101025).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.