ArticleMedical physics2025
An absorbed dose-based source strength determination for diffusing alpha-emitters radiation therapy (DaRT) brachytherapy seeds - Proof of concept.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiffusing alpha-emitter radiation therapy (DaRT) is currently being evaluated in several clinical trials as an interstitial temporary brachytherapy source. However, determining source strength solely based on gamma spectrometry measurements of PURPOSE: There were two aim of this work. The first aim was to investigate the impact of
methodsA MC model of the DaRT seed was constructed with varying
resultsThe progeny desorption was found to be highly sensitive to the distribution depth parameter with a sharp reduction in desorption probabilities with increasing distribution depth. The cumulative absorbed dose to tumor was found to vary drastically with the desorption probabilities with dose differences of up to 80%. Despite large dose differences, the 10-Gy prescription isodose line was found to be within 1 mm of each other indicating a spatial shift due to differences in desorption. The absorbed dose standard was found to have a signal > 7 pA with high sensitivity to the changes in the desorption probabilities. The MC-calculated correction factors were found to be < 3% with negligible dependence on the changes in desorption.
conclusionsThis work investigated and reported a large dependence of absorbed dose to water on desorption of
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