ArticleJournal of applied clinical medical physics2025
Evaluation of treatment planning feasibility of a positron emission tomography (PET)-Linac system for spine stereotactic body radiotherapy (SBRT).
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Evaluation of treatment planning feasibility of a positron emission tomography (PET)-Linac system for spine stereotactic body radiotherapy (SBRT).Journal of applied clinical medical physics · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
background and purposeThe RefleXion X1 (RefleXion Medical, Inc., Hayward, CA) is a unique radiotherapy platform integrating kVCT and PET as on-board imaging guidance. This study aims to evaluate the feasibility and treatment planning quality of RefleXion X1 treatment planning system (TPS) for spinal stereotactic body radiation therapy (SBRT).
methodsThis retrospective study analyzed treatment plans of 10 different patient cases, including five single-dose level SBRT cases and five simultaneously integrated boost (SIB) SBRT cases. All plans were created using the X1 TPS with a 10 mm jaw size and evaluated against institutional planning guidelines to ensure clinical acceptability. To assess planning quality, the X1-generated plans were compared to clinically treated plans. Key metrics such as planning target volume (PTV) coverage, maximum point dose (measured as maximal dose to any volume of 0.035cc), conformity index (CI), and organs-at-risk (OARs) constraints were evaluated. Statistical analysis was performed using the Wilcoxon signed-rank test, with significance defined as p < 0.05.
resultsAll RefleXion X1 plans met our institutional planning guidelines for spinal SBRT and were deemed clinically acceptable. No statistically significant differences were observed in all PTV metrics, including
conclusionsThe RefleXion X1 system can generate clinically acceptable treatment plans for complex spinal SBRT, with plan quality comparable to that of clinically treated plans at our institution.
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