Evidence map›Paper›PMID 41317394›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes.

Sijia Wang, Meiyun Wang, Peng Zhang, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu and 42 more

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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genome-Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

Sijia WangDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Meiyun WangDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, 450003, China.
Peng ZhangDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
Jingliang ChengDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Longjiang ZhangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, China.
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Shijun QiuDepartment of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405, China.
Zuojun GengDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China.
Guangbin CuiFunctional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China.
Yongqiang YuDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Weihua LiaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xi-Nian ZuoDevelopmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.
Hui ZhangDepartment of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Bo GaoDepartment of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.
Xiaojun XuDepartment of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, China.
Tong HanDepartment of Radiology, Tianjin Huanhu Hospital, Tianjin, 300350, China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Quan ZhangDepartment of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, 300162, China.
Feng LiuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Qiang XuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Jiayuan XuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Jilian FuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Nana LiuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Yuan JiDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Jie TangDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Lining GuoDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Mengge LiuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Xiaoxiao XiaoSchool of Medical Imaging (School of Medical Technology) and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China.
Xiaoxuan LiuMinistry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing, 100084, China.
Wei LiDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
Caihong WangDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Wei WeiDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, 450003, China.
Dapeng ShiDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, 450003, China.
Su LuiDepartment of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, 610041, China.
Zhihan YanDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, China.
Feng ChenDepartment of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, 570311, China.
Jing ZhangDepartment of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, 730030, China.
Wen ShenDepartment of Radiology, Tianjin First Center Hospital, Tianjin, 300192, China.
Yanwei MiaoDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Dawei WangDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Jia-Hong GaoCenter for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Yunjun YangDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Kai XuDepartment of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, China.
Junfang XianDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Bing ZhangDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210008, China.
Xiaochu ZhangDivision of Life Science and Medicine, University of Science & Technology of China, Hefei, 230027, China.
Zhaoxiang YeDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
Le YuMinistry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing, 100084, China.
Wen QinDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Meng LiangSchool of Medical Imaging (School of Medical Technology) and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, 300203, China.
Chunshui YuDepartment of Radiology, Tianjin Key Lab of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.ORCID https://orcid.org/0000-0001-5648-5199
CHIMGEN Consortium

Funding

China Postdoctoral Science Foundation 2024M762387National Key R&D Program of China 2024YFF1307600National Natural Science Foundation of China 81971599National Natural Science Foundation of China 82030053National Natural Science Foundation of China 82430063National Natural Science Foundation of China 82472052
6 · The paper itself

Abstract

Brain structure and function show substantial individual differences, finely controlled by genes, environments, and their interactions. Despite the increasing knowledge about genetic and environmental main effects, gene-environment interaction effects on brain phenotypes remain elusive. This study investigates genome-wide by environment (41 exposures) interactions on 598 brain imaging phenotypes in 7084 healthy young adults. Both univariate and multivariate analyses identify 486 significant gene-environment interactions, scattered across the genome, exposome, and phenome. These interactions explain more variances of phenotypes than genetic and environmental main effects (100% of genetic and 96% of environmental main effects are non-significant). Variants with interactions are enriched in intronic and intergenic regions, comprising 79 regulatory variants and 145 associated with brain gene expression. Protein-protein interaction network analyses reveal distinct interaction networks for genes associated with air pollution (hubs: H4C6, SMARCA4, and RPS11) and urbanicity (hubs: CCND1, CALM3, and CDK2) exposures. Genes that interacted with air pollution exposures exhibit enrichment in pathways related to metal ion detoxification and homeostasis. For time-varying exposures, 144 interactions demonstrate sensitive periods, predominantly in childhood (ages 4-7) and adolescence (ages 12-15). These findings highlight the value of genome-wide by exposome-wide interaction studies, which may offer crucial information for optimizing brain health outcomes.

Indexed as

BrainGene-Environment InteractionNeuroimagingAdolescentAdultChildEnvironmental ExposureFemaleGenome-Wide Association StudyHumansMalePhenotypeYoung Adultbrain imaging phenotypesgene‐environment interactionsmain effectssensitive periods

Identifiers

PMID41317394
PMCPMC12884788

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