ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
One-Step Coaxial 3D Printing of Pre-Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Sprayable bioadhesive microcarriers loaded with Tβ4-Engineered ADSC exosomes for diabetic wound healing.Bioactive materials · 2026Article
- [Research advances on the application of skin appendage organoids in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- [Skin organoids: an emerging platform from three-dimensional construction to regenerative application].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Application of 3D-Bioprinting in Treatment of Chronic Wounds: A Review.Life (Basel, Switzerland) · 2026Review
- 3D bioprinted composite scaffold incorporating microfluidics-derived chondrocyte microspheroids promotes auricular cartilage regeneration.Materials today. Bio · 2026Article
- One-Step Coaxial 3D Printing of Pre-Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Biomimetic hydrogel design strategies for vascular grafts and vascularized tissue constructs.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Organoids are important tools for studying organ development, drug screening, and regenerative medicine, yet the absence of integrated vasculature limits their culture and translation. To address this, the PV-XOM strategy is proposed, which achieves one-step construction of pre-vascularized organoids through coaxial bioprinting: the inner phase uses temperature-responsive sacrificial material and endothelial cells to form hollow vascular channels, while the outer phase is a biomimetic hydrogel matrix containing organoid microspheres. Based on this framework, a pre-vascularized skin organoid model (PV-SOM) is established, in which the outer phase is loaded with adipose-derived stem cell (ADSC) microspheres and skin fibroblasts. In vitro, PV-SOM achieved rapid vascular closure and maturation; in vivo, it formed abundant neovessels in large skin defects, accelerated wound closure, and improved collagen remodeling. Proteomic analysis further revealed that ADSC microspheres activate the PI3K-AKT-mTOR pathway to regulate vascular formation across multiple stages. These findings show that PV-XOM offers an effective, scalable solution to the vascularization bottleneck of organoids with strong translational potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.