ArticleDigestive diseases and sciences2026
Characteristics of the Esophageal Microbiota in Patients with Achalasia.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAchalasia (AC) is clinically characterized by chronic intraluminal food stasis and bacterial fermentation, which may contribute to esophageal dysbiosis. This research seeks to analyze the microbiome of individuals with AC, pinpoint significant biomarkers, and explore their relationships with clinical and electrophysiological factors to enhance our comprehension of the mechanisms underlying AC.
methodsThis study, conducted at a single center, involved 16S rRNA sequencing of esophageal mucosal samples collected from individuals with achalasia and a control group. We assessed microbial diversity, identified distinct taxa using LEfSe, predicted functional capabilities through PICRUSt, and examined the relationship between microbiota and clinical parameters. Biomarkers were identified using a random forest algorithm and subsequently validated through qPCR.
resultsPatients with achalasia displayed notable dysbiosis in their esophageal microbiome, marked by changes in community structure while showing no significant shifts in diversity. There was a marked increase in the opportunistic bacterium Fusobacterium, alongside a reduction in beneficial species such as Akkermansia and Ligilactobacillus. The presence of Pseudomonas and Ralstonia was linked to the Eckardt score. The rise in Fusobacterium was further validated through qPCR analysis. Functional predictions suggested an increase in acetyl-CoA biosynthesis among these patients. Notably, levels of Fusobacterium were positively associated with critical clinical indicators, including pressures in the lower and upper esophageal sphincters and the Eckardt score.
conclusionsEsophageal dysbiosis is associated with esophageal hypomotility in achalasia patients.
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