Evidence map›Paper›PMID 41317225›Full record

ArticleDigestive diseases and sciences2026

Prevalence of Precursor Lesions in Gastric Adenocarcinoma Specimen: Insights into Pathogenesis in the United States Population.

Jameel Alp, Erica Loon, Amir Sultan Seid, Natalie Wilson, Juan C Manivel, Brian Hanson, Rahul Karna, Mohammad Bilal

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jameel AlpDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Erica LoonDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Amir Sultan SeidDivision of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Natalie WilsonDivision of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Juan C ManivelDepartment of Pathology and Laboratory Medicine, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
Brian HansonDivision of Gastroenterology and Hepatology, Department of Medicine, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
Rahul KarnaDivision of Gastroenterology and Hepatology, Department of Medicine, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
Mohammad BilalDivision of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. billa17@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric adenocarcinoma (GAC) remains a major public health concern in the U.S., characterized by late presentation and poor outcomes. While the Correa cascade describes a multistep progression from precursor lesions (PLs) to cancer, its applicability to U.S. GAC cases remains uncertain.

aimsTo evaluate the prevalence of histologic PLs in patients diagnosed with GAC and assess opportunities for earlier detection.

methodsWe conducted a retrospective review of patients diagnosed with GAC at a tertiary care center from 2003 to 2023. Histologic PLs including atrophic gastritis, gastric intestinal metaplasia (GIM), and dysplasia were identified in GAC resection specimens. Prior esophagogastroduodenoscopy (EGD) and Helicobacter pylori data were also reviewed. Comparisons were made across clinical, histologic, and treatment characteristics by PL presence in GAC resection specimens.

resultsAmong 118 patients (97.5% male, mean age 72.6), PLs were present in 35.6% of GAC resection specimens, most commonly GIM (78.6%). Of these, 26.2% had undergone prior EGD, and only 36.4% had previously documented PLs. Intestinal-type GAC was more common in patients with PLs (73.8 vs. 18.4%, p < 0.001), while diffuse-type predominated in those without. Time from H. pylori diagnosis to GAC was longer in patients with PLs (222 vs. 166 months, p = 0.03), but only 33.9% had H. pylori testing prior to diagnosis.

conclusionsOver one-third of GAC cases had PLs present at diagnosis, yet few had prior endoscopic detection, highlighting missed prevention opportunities.

Indexed as

AdenocarcinomaPrecancerous ConditionsStomach NeoplasmsAgedAged, 80 and overFemaleGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriHumansMaleMetaplasiaMiddle AgedPrevalenceRetrospective StudiesUnited StatesAtrophic gastritisCorrea cascadeGastric adenocarcinomaGastric intestinal metaplasiaHelicobacter pyloriPrecursor lesions

Identifiers

PMID41317225

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