ArticleBrain structure & function2025
Precerebellar paramedian tract cell group connections: II. Abducens internuclear inputs.
Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Our previous study showed that oculomotor internuclear neurons project to precerebellar populations lying in the paramedian tract cell groups, in addition to projecting to the abducens nucleus. Consequently, we posited that the abducens internuclear neurons might have similar projections, beyond their well-recognized projection to the oculomotor nucleus. With this in mind, we examined macaque monkey cases with abducens nucleus injections of anterograde tracers. As with oculomotor internuclear neurons, we found terminal fields in paramedian tract cell groups. These abducens nucleus injections, also involved precerebellar projection cells located in the infragenual and supragenual regions. This was evidenced by the presence of labeled terminal arbors within the flocculus. Unexpectedly, we also noted previously undescribed labeled terminal arbors within the fastigial nucleus. Consequently, we tested whether the paramedian tract cell groups also project to this deep cerebellar nucleus. Injections of tracer into the fastigial nucleus retrogradely labeled neurons within the infragenual and supragenual regions, and in other components of the paramedian tract cell groups. Taken together with the previous study, we have strong neuroanatomical evidence suggesting that both the oculomotor and abducens internuclear projections provide a horizontal gaze efference copy signal to the cerebellum via the precerebellar populations located in the paramedian tract cell groups. In addition to supplying these signals to the flocculus, they also supply input to the fastigial nucleus. Thus, the internuclear projections may allow the fastigial nucleus and flocculus to appropriately modulate both conjugate and vergence eye movements by comparing the output signal to the actual movements produced.
Indexed as
Identifiers
41317202What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.