Evidence map›Paper›PMID 41317184›Full record

ArticleBrain structure & function2025

Distinct cellular localization of α- synuclein and β-synuclein in the chick retina.

Fang He, Lin Liu, Shaoxuan Wang, Xin Lin, Guiyu Guan, Xiaoqian Lai, Xi Yu, Xiaotian Wu, Zhihao Shen, Bilin Rao and 3 more

Abstract read
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In one paragraph

Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fang He *State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Lin Liu *State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Shaoxuan WangState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Xin LinState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Guiyu GuanState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Xiaoqian LaiState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Xi YuLaboratory of Retinal Physiology and Disease, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Xiaotian WuState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Zhihao ShenState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Bilin RaoState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Mei-Ling GaoState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Xuejiao ChenState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. chenxuejiao1022@163.com.
Jun ZhangState Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. zj9999@eye.ac.cn.

Funding

National Key Research and Development Program of China 2022YFA1105503
6 · The paper itself

Abstract

α-Synuclein and β-synuclein are critical regulators of synaptic function and play significant roles in physiology and disease. While their retinal expression patterns are well-characterized in mammals, limited studies exist for the chicken retina, a model valuable for studying human retinal degenerative diseases due to its cone-dominant photoreceptor structure. Notably, research on β-synuclein in chickens remains scarce, leaving synucleinopathy models underdeveloped. Using immunofluorescence, we analyzed α- and β-synuclein expression in the chicken retina. Our results show that β-synuclein has a broader distribution than α-synuclein, similar to mouse retinas. Unique to chickens, α- and β-synuclein were highly expressed in horizontal cells, a feature absent in mice. Additionally, most dopaminergic and cholinergic amacrine cells co-expressed both α- and β-synucleins, unlike the mouse retina. These findings highlight species-specific differences in synuclein expression, providing insights into their roles in retinal function and pathology. This research may advance understanding of synucleinopathies and aid in the development of diagnostic and therapeutic strategies for neurodegenerative diseases.

Indexed as

alpha-Synucleinbeta-SynucleinRetinaAmacrine CellsAnimalsChickensMiceRetinal Horizontal CellsSpecies Specificityalpha-Synucleinbeta-SynucleinChickLocalizationRetinaα-synucleinβ-synuclein

Identifiers

PMID41317184

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.