ArticleRheumatology international2025
Prevalence and synergistic impact of neuropathic pain and fibromyalgia on disability and quality of life in multiple sclerosis: a cross-sectional study.
Article in Rheumatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Neuropathic pain versus restless legs syndrome: distinct and combined effects on balance and walking performance in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the effects of neuropathic pain and fibromyalgia syndrome (FMS) on the quality of life of patients with multiple sclerosis (MS), as assessed by functional status, disability, pain intensity, mood, and sleep quality. A total of 190 MS patients (137 females, 53 males; mean age: 45.2 ± 11.5 years; range: 20-72 years) were included in this cross-sectional study. Pain, functional status and disability of the patients were evaluated using the following tools: visual analog scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), Douleur Neuropathique 4 Questions (DN4), Kurtzke Expanded Disability Status Scale (EDSS), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI) and Health Assessment Quality (HAQ) questionnaires. Neuropathic pain and FMS were present in 34.7% and 32.6% of the patients, respectively. The presence of both conditions was strongly associated with significantly worse scores across all tested parameters (VAS, BDI, FIQ, PSQI, EDSS, and HAQ) (p < 0.05). On most of the tools tested, male patients scored better than female patients (p < 0.05). Neuropathic pain and FMS are very common conditions in MS patients, and they appear to be associated with impaired quality of life, impaired functional status, and disability.
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