Evidence map›Paper›PMID 41317151›Full record

ArticleGigaScience2025

Cervical whole-slide images dataset for multiclass classification.

Mahnaz Mohammadi, Christina Fell, David Morrison, Sarah Bell, Gareth Bryson, Sheeba Syed, Prakash Konanahalli, David Harris-Birtill, Ognjen Arandjelovic, Clare Orange and 4 more

Abstract readDataset
In one paragraph

Article in GigaScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mahnaz MohammadiSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom.ORCID 0000-0002-3109-4324
Christina FellSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom.ORCID 0000-0003-0590-4132
David MorrisonSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom.ORCID 0000-0001-5502-9773
Sarah BellDepartment of Pathology, Queen Elizabeth University Hospital, Glasgow, G51 4TF, United Kingdom.ORCID 0000-0003-1181-7144
Gareth BrysonDepartment of Pathology, Queen Elizabeth University Hospital, Glasgow, G51 4TF, United Kingdom.ORCID 0000-0003-2734-309X
Sheeba SyedDepartment of Pathology, Queen Elizabeth University Hospital, Glasgow, G51 4TF, United Kingdom.ORCID 0009-0001-8221-6459
Prakash KonanahalliDepartment of Pathology, Queen Elizabeth University Hospital, Glasgow, G51 4TF, United Kingdom.ORCID 0000-0001-7270-630X
David Harris-BirtillSchool of Computer Science, University of St Andrews, North Haugh, St Andrews, KY16 9SX, United Kingdom.ORCID 0000-0002-0740-3668
Ognjen ArandjelovicSchool of Computer Science, University of St Andrews, North Haugh, St Andrews, KY16 9SX, United Kingdom.ORCID 0000-0002-9314-194X
Clare OrangeSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom.ORCID 0000-0001-9155-3468
Prishma ShahiSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom.
In Hwa UmSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom.ORCID 0000-0001-9999-4292
James D BlackwoodSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom.ORCID 0000-0002-1685-6108
David J HarrisonSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, United Kingdom.ORCID 0000-0001-9041-9988

Funding

UKRI 104690
6 · The paper itself

Abstract

backgroundThe clinical pathway for the prevention and treatment of cervical cancer depends on cytology and then the assessment of biopsy specimens, fragments of tissue removed for histological examination. This can be a significant workload and is an obvious exemplar to explore triage based on machine learning analysis of slides. Limited access to large annotated datasets of human diseased tissue is a major obstacle to developing standards and algorithms that can assist diagnosis.

resultsWe present a dataset comprising 2,539 whole-slide images of cervical biopsy specimens, each annotated by several pathologists and consensus on diagnosis and individual features agreed. Each whole-slide image represents 1 slide per patient in iSyntax format, with manual annotations by pathologists in Jason format. Each whole-slide image is assigned a category label, which is the final diagnosis of the image, and a subcategory label, which declares in which subcategory the image is found.

conclusionThis dataset has been used to build a model that accurately predicts diagnosis, allowing the possibility of automatically triaging biopsy specimens, so that the most significant pathologies can be identified rapidly and those patients selected for immediate treatment. The level of annotation, at the subslide level, and the number of cases are unique in public databases and should allow investigators to explore multiple aspects of computer vision relevant to human tissue diagnosis, with no limitation placed on access to the whole-slide images.

Indexed as

Cervix UteriImage Processing, Computer-AssistedUterine Cervical NeoplasmsAlgorithmsBiopsyFemaleHumanscervical cancercervixdeep learningdigital image databasehealth care datasethistopathologymachine learningwhole-slide imaging

Identifiers

PMID41317151
PMCPMC12751090

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.