Evidence map›Paper›PMID 41316981›Full record

ArticleJournal of psychopharmacology (Oxford, England)2025

(-)-OSU6162 reduces freezing elicited by context-conditioned fear in rats.

Daniela Atanasovski, Sven Melker Hagsäter, Marcus Myrehag, Karl Arheden, Sandra Sjöblad, Elias Eriksson

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In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniela AtanasovskiDepartment of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Sven Melker HagsäterDepartment of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Marcus MyrehagDepartment of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Karl ArhedenDepartment of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Sandra SjöbladDepartment of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Elias ErikssonDepartment of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.ORCID 0000-0002-4128-2046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective(-)-OSU6162 is an antagonist at dopaminergic D

methodsThe impact of (-)-OSU6162 and amphetamine on the expression of freezing was assessed in rats exposed to contextual fear conditioning using electrical foot shocks. It was also assessed whether the increase in activity observed in animals treated with (-)-OSU6162 could be countered by pretreatment with a D

resultsWhile (-)-OSU6162 markedly reduced freezing behaviour, amphetamine abolished it completely. The effect of (-)-OSU6162 was countered by raclopride but neither by MDL100907 nor by BD1063.

conclusion(-)-OSU6162 reduces the expression of context-conditioned fear displayed as freezing by a mechanism involving D

Indexed as

Conditioning, PsychologicalDopamine D2 Receptor AntagonistsFearFreezing Reaction, CatalepticPiperidinesAmphetamineAnimalsBehavior, AnimalMaleMotor ActivityRatsRats, WistarReceptors, Dopamine D2Receptor, Serotonin, 5-HT2AReceptors, sigmaSigma-1 ReceptorAmphetamineDopamine D2 Receptor AntagonistsOSU 6162PiperidinesReceptors, Dopamine D2Receptor, Serotonin, 5-HT2AReceptors, sigmaSigma-1 Receptor5-HT2A receptoramphetaminedopamine D2 receptorOSU6162sigma receptor

Identifiers

PMID41316981
PMCPMC12672934

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.