ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Smart Hydrogel Doped by Metal-Organic Frameworks for Renewable Self-Pumping Enzymatic Reactors.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Smart Hydrogel Doped by Metal-Organic Frameworks for Renewable Self-Pumping Enzymatic Reactors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The construction of high-performance immobilized enzymes is vastly desired for green biotransformation. Although hydrogels offer significant potential for facilitating biomedical applications of enzymes due to their flexibility, macroscopic processability, and extracellular matrix-like properties. However, maintaining enzymatic activity and recyclability within bulk hydrogels remains a formidable challenge due to restricted passive mass transfer and enzyme leakage. Herein, inspired by the heart's blood-pumping mechanism, a smart metal-organic framework (MOFs)-doped hydrogel is developed for enzyme immobilization to effectively address these challenges. Importantly, thermally triggered contraction/expansion cycles of the hydrogel, coupled with a dynamic water stream, significantly enhance substrates intake and endogenous products expulsion, while enzymes are effectively retained due to the interception effect of MOFs. This activity can be tuned by adjusting hydrogel contractility, enabling active mass transfer and regeneration similar to living tissues. Benefit from these advantages, the biosystems perform well in biosensing applications. This study provides a novel solution for enzymatic immobilization in porous 3D matrices and opens opportunities for the construction of life-like bio-microdevices or artificial organelles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.