Evidence map›Paper›PMID 41316841›Full record

ArticleJournal of the science of food and agriculture2026

Integrated green extraction of phenolic compounds and fermentable sugars from grapefruit peel using ultrasound and enzymatic hydrolysis.

María Del Prado García-Aparicio, María Castro-Puyana, María Luisa Marina

Abstract readEvaluation Study
In one paragraph

Article in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

María Del Prado García-AparicioUniversidad de Alcalá, Departamento de Química Analítica, Química Física e Ingeniería Química, Campus Universitario, Alcalá de Henares, Spain.ORCID https://orcid.org/0000-0001-5312-6561
María Castro-PuyanaUniversidad de Alcalá, Departamento de Química Analítica, Química Física e Ingeniería Química, Campus Universitario, Alcalá de Henares, Spain.ORCID https://orcid.org/0000-0003-1412-4103
María Luisa MarinaUniversidad de Alcalá, Departamento de Química Analítica, Química Física e Ingeniería Química, Campus Universitario, Alcalá de Henares, Spain.ORCID https://orcid.org/0000-0002-5583-1624

Funding

Junta de Comunidades de Castilla-La Mancha and European SBPLY/21/180501/000217Spanish Ministry of Science, Innovation and Universities and the European Union TED2021-131011B-I00University of Alcalá PIUAH23/CC-060;PTUAH23/006
6 · The paper itself

Abstract

backgroundValorizing sugar-rich food waste in biorefineries offers a sustainable route to bio-based products. Grapefruit peel (GP), representing about 50% of the fruit's weight, is rich in sugars (soluble and insoluble) and polyphenols such as flavonoids. The present study investigates an integrated green extraction strategy using high-intensity focused ultrasound (HIFU) and enzymatic hydrolysis (EH) to recover phenolic compounds and sugars from GP.

resultsVacuum-drying preserved extractability and sugars release with the carbohydrases evaluated. Using dried GP at 10% (DW/v), EH incorporating lytic polysaccharide monooxygenases yielded >60 g L

conclusionSequential HIFU-EH offers an efficient, sustainable approach to valorize GP, reducing solvent and time requirements at the same time as co-producing bioactive phenolics and fermentable sugars in separate steps, thereby avoiding phenolic inhibition during subsequent biological steps. The process enhances antioxidant and antimicrobial properties and supports potential applications in food, nutraceutical and biorefinery sectors. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

CarbohydratesChemical FractionationCitrus paradisiGreen Chemistry TechnologyPhenolsPlant ExtractsSugarsAntioxidantsFermentationFruitHumansHydrolysisAntioxidantsCarbohydratesPhenolsPlant ExtractsSugarscoumarinsenzyme‐based technologyfood waste biorefinerygrapefruit peelhigh‐intensity focused ultrasound (HIFU)sequential extraction

Identifiers

PMID41316841
PMCPMC12790642

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.