ArticlePlant biotechnology journal2026
The TaMADS2-TaTBL21 Module Enhances Wheat Resistance to Stripe Rust by Activating TaGKL-Mediated Immunity.
Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A cooperative regulatory module between TAGL2 and JMJC1 activates specific defense genes against root-knot nematodes in tomato.The New phytologist · 2026Article
- Functional Analysis of MADS-Box Gene Family in Stress Response and Prospects of Breeding Application.Plants (Basel, Switzerland) · 2026Review
- Roles of MADS-box transcription factors in plant responses to abiotic and biotic stresses.Plant communications · 2026Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Wheat stripe rust (Puccinia striiformis f. sp. tritici, Pst) poses a catastrophic threat to global food security. While MADS-box transcription factors regulate development and abiotic stress, their roles in plant-pathogen immunity remain enigmatic. In this study, we identified TaMADS2, a Pst-induced MADS-box gene, as a positive regulator of wheat resistance. Functional analyses demonstrated that TaMADS2 overexpression significantly enhanced Pst resistance, whereas its knockdown rendered wheat more susceptible. Further investigation revealed that TaMADS2 interacts with trichome birefringence-like protein 21 (TaTBL21) to activate glycerol kinase-like (TaGKL) expression. Silencing TaGKL in wild-type or TaMADS2-overexpressing lines compromised resistance, with elevated Pst biomass. Notably, dual silencing of TaMADS2 and TaGKL further heightened susceptibility, confirming their synergistic defence role. Mechanistically, the TaMADS2-TaTBL21 complex promotes wheat resistance to stripe rust disease by upregulating TaGKL expression, leading to the accumulation of the key defence metabolites salicylic acid (SA) and glycerol-3-phosphate (G3P). Our study unveils a novel TaMADS2-TaTBL21-TaGKL module that potentiates wheat resistance against stripe rust, offering strategic targets for breeding resistant wheat.
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