Evidence map›Paper›PMID 41316478›Full record

ArticleEuropean journal of medical research2025

The impact of early nutritional support on in-hospital mortality in patients with sepsis caused by bacterial or viral infections: a retrospective cohort study.

Lihong Xu, Jinlong Wang, Xinyi Yin, Qing Li, Hui Chen, Haofei Wang, Wenhan Hu, Qingyun Peng, Shuhe Yang, Shanshan Meng and 2 more

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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Lihong Xu *Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Jinlong Wang *Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Xinyi YinJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Qing LiJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Hui ChenJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Haofei WangJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Wenhan HuJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Qingyun PengJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Shuhe YangJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Shanshan MengJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Wei HuangJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Yingzi HuangJiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China. yz_huang@126.com.

Funding

China Postdoctoral Science Foundation 2022M710685Health Research Program of Anhui AHWJ2024Aa30008National Key Research and Development Program of China 2022YFC2304604National Natural Science Foundation of China 82472201National Natural Science Foundation of China 824B2062
6 · The paper itself

Abstract

backgroundThe impact of pathogen type on the relationship between early nutritional support and prognosis in sepsis patients remains unclear. This study aims to evaluate the effect of early nutritional support on in-hospital mortality in patients with sepsis caused by viral or bacterial infections. MATERIALS AND

methodsA retrospective cohort study was conducted, including adult patients with sepsis admitted to the intensive care unit (ICU) of Zhongda Hospital, Southeast University, between 2016 and 2023. Early nutritional support was defined as initiating nutritional support within 48 h of sepsis diagnosis. Patients were stratified based on pathogen type, and propensity score matching (PSM) and inverse probability weighting (IPW) were used to adjust for confounding factors. Logistic regression analysis was performed to assess the effect of early nutritional support on in-hospital mortality.

resultsA total of 2,278 patients with sepsis were included (119 viral and 2,159 bacterial). After adjustment, in the viral sepsis group, early nutritional support was associated with a lower in-hospital mortality compared to delayed support (25.0% vs. 30.0%, aOR 0.79, 95% CI 0.63-0.99, p = 0.046). In contrast, in the bacterial sepsis group, early nutritional support showed no significant benefit for in-hospital mortality (16.3% vs. 18.5%, aOR 1.02, 95% CI 0.98-1.06, p = 0.328). For bacterial sepsis, early support was associated with longer ICU length of stay and duration of mechanical ventilation among survivors.

conclusionEarly nutritional support may offer a potential survival benefit in patients with viral sepsis. Given the small size and borderline statistical significance, these findings should be interpreted with caution and require further validation through prospective randomized controlled trials.

Indexed as

Bacterial InfectionsHospital MortalityNutritional SupportSepsisVirus DiseasesAgedFemaleHumansIntensive Care UnitsMaleMiddle AgedPrognosisRetrospective StudiesCritical care medicineMortalityNutritional supportPathogenSepsis

Identifiers

PMID41316478
PMCPMC12664256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.