Rapid treatment of depression with potassium supplementation: relative deficiency of potassium ions and possible pathogenesis-a case report.

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In one paragraph

Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jiapei DaiWuhan Institute for Neuroscience and Neuroengineering, South-Central Minzu University, Minzu Dadao 182, Wuhan, 430074, China. jdai@mail.scuec.edu.cn.ORCID http://orcid.org/0000-0002-1474-5754

Funding

Fundamental Research Funds for Central Universities of the Central South University CZP 18003the innovation team fund of National Ethnic Affairs Commission (No. MZR20002) MZR20002

6 · The paper itself

Abstract

backgroundDespite advances in depression research and treatment, effective strategies based on clear neural mechanisms are still lacking. Current therapies often show delayed effects and inconsistent outcomes, suggesting that the core pathophysiology remains unclear. CASE PRESENTATION: This case report describes a highly successful and rapid resolution of subacute mild anxiety and severe depression in a 32-year-old woman of Chinese origin following treatment with potassium ion supplementation. It explores the potential mechanisms underlying this therapeutic effect, highlighting the role of relative potassium ion deficiency in the pathogenesis of depression.

conclusionThis case achieved significant therapeutic outcomes through innovative treatment strategies, raising an interesting possibility on the pathogenesis of depression. However, more clinical observations or cohort studies are needed to support this finding.

Indexed as

DepressionDietary SupplementsPotassiumPotassium DeficiencyAdultFemaleHumansTreatment OutcomePotassiumAnxietyCase reportDepression anxietyPotassium supplementationRelative deficiency of potassium ions

Identifiers

PMID41316473

DOI10.1186/s13256-025-05693-2

PMCPMC12664267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.