ArticleJournal of cardiothoracic surgery2025
Association between the peak red blood cell distribution width and in-hospital mortality after post-cardiotomy extracorporeal membrane oxygenation.
Article in Journal of cardiothoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
backgroundRed blood cell distribution width (RDW) is a marker that routinely describes circulating erythrocytes variability and may hold potential prognostic value in cardiac surgery. Our objective is to evaluate the association between peak values of RDW and in-hospital mortality among patients receiving post-cardiotomy veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support.
methodsThis single-center, retrospective study included adult patients receiving post-cardiotomy V-A ECMO support between January 2017 and December 2024. The association between peak values of RDW and in-hospital mortality was assessed by multivariable logistic regression model. Spearman correlation analysis was used to determine the correlations between related laboratory factors and peak values of RDW.
resultsA total of 106 patients were included and in-hospital mortality rate was 54.7%. After adjusting for confounding factors, increased peak values of RDW during ECMO support were significantly associated with higher risk of in-hospital mortality (aOR, 2.097; 95% CI, 1.328–3.312; p = 0.001). Peak values of RDW were negatively correlated with lowest values of hemoglobin and positively correlated with peak values of lactate dehydrogenase (LDH), direct bilirubin (DBil), total bilirubin (TBil), neutrophil-to-lymphocyte ratio (NLR) and fibrinogen degradation products (FDP) occurring within ± 12 h of the RDW peak levels.
conclusionsIn patients receiving post-cardiotomy V-A ECMO, the peak values of RDW might be an independent prognostic factor for in-hospital mortality. Potential factors related to increased peak values of RDW included hemolysis, systemic inflammatory responses, and coagulation dysfunction.
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