ArticleDiabetology & metabolic syndrome2025
Longitudinal correlation between cumulative remnant cholesterol inflammatory index and incident diabetes.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Two-Time-Point Inflammatory Status Patterns and the Risk of Incident Diabetes: A Cohort Study Based on CHARLS.Healthcare (Basel, Switzerland) · 2026Article
- Association between non-traditional lipid-inflammatory parameters and incident diabetes: a national prospective cohort study.BMC endocrine disorders · 2026Article
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3 authors.
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Abstract
backgroundDiabetes is closely associated with dyslipidemia and inflammation. However, studies on the combined effects of inflammation and dyslipidemia on incident diabetes are lacking. Remnant cholesterol inflammation index (RCII) is a clinical indicator of inflammation and dyslipidemia. In this study, we aimed to investigate the longitudinal relationship between cumulative RCII (cumRCII) and incident diabetes.
methodsData were sourced from the China Health and Retirement Longitudinal Study from 2011 to 2018. The mean age of the study participants was 58 years. CumRCII was treated as the exposure variable and incident diabetes as the outcome variable. Restricted cubic splines and logistic regression were used to evaluate the relationship between cumRCII and incident diabetes, and longitudinal targeted maximum likelihood estimation used for sensitivity analysis.
resultsA total of 4,513 participants were included in the analysis. During a 7-year follow-up period, 302 cases of incident diabetes were diagnosed. Using the first quartile of cumRCII as the reference, the odds ratio (OR) for incident diabetes in the fourth quartile was 2.60 (OR = 2.60; 95% confidence interval [CI], 1.74–3.87; P < 0.001). Each standard deviation increase in cumRCII, the OR for incident diabetes was 1.26 (OR = 1.26; 95% CI, 1.16–1.37; P < 0.001). Sensitivity analysis yielded consistent conclusions, with the Net Reclassification Improvement (NRI) for the model incorporating cumRCII being 0.346 and the DeLong test showing statistical significance. We found a nonlinear relationship between cumRCII and incident diabetes, the threshold value of cumRCII with respect to incident diabetes was 43.39.
conclusionsCumRCII is closely associated with incident diabetes in adults aged ≥ 45 years, and a significant correlation was found between cumRCII and incident diabetes in the population with normal triglyceride levels. Furthermore, the longitudinal relationship between cumulative RCII and incident diabetes was non-linear. CumRCII can be used as an early indicator of incident diabetes in a population with normal triglycerides.
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