ReviewMalaria journal2025
Unusual replication dynamics during Plasmodium falciparum schizogony.
Review in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmodium falciparum causes the most severe form of malaria in humans, and disease severity is directly linked to parasite proliferation during the erythrocytic cycle. During this cycle, P. falciparum replicates via schizogony. This is an unusual form of asexual replication in which the parasite undergoes alternating asynchronous rounds of DNA replication and nuclear division within a shared cytoplasm, followed by a mass cytokinesis event that produces numerous daughter cells. Despite recent advances in high-throughput, single-molecule techniques, clarity on P. falciparum replication dynamics remains elusive. These dynamics are likely shaped by its highly AT-rich genome and the unique pressures of schizogony. Clarifying the pressures that shape schizogony and DNA replication may reveal parasite-specific vulnerabilities and inform the development of new antimalarials.
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Registered trials
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