Evidence map›Paper›PMID 41316156›Full record

ArticleBMC medicine2025

Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults.

Xue Dong, Paul Aveyard, Xiaochen Yang, Mika Kivimaki, Shanquan Chen, Joseph Firth, Cynthia Wright Drakesmith, Min Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xue DongNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.
Paul AveyardNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.
Xiaochen YangNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.
Mika KivimakiUniversity of Helsinki, Helsinki, Finland.
Shanquan ChenSchool of Public Health, The University of Hong Kong, Hong Kong, China.
Joseph FirthDivision of Psychology and Mental Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Cynthia Wright DrakesmithNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.
Min GaoNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. min.gao@phc.ox.ac.uk.

Funding

Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8M
a UK Research and Innovation Future Leaders Fellowship MR/Y033876/1China Scholarship Council program 202306010289China Scholarship Council program 202406010160NIA NIH HHS R01AG056477Wellcome Trust 221854/Z/20/Z
6 · The paper itself

Abstract

backgroundWhether both high and low BMI are risk factors for mental illnesses is unclear, especially serious mental illnesses. Experimental evidence suggests that metabolic pathways might mediate the association, but this is uncertain. To examine associations between BMI and the first-onset of diagnosed mental illnesses with assessment for mediating effects of cardiometabolic disorders.

methodsUsing the UK Clinical Practice Research Datalink (2000-2022), individuals ≥ 18 years with a recorded BMI assessment were included. Diagnosed mental illnesses were ascertained via clinical diagnoses, referrals to mental health services, or psychotropic prescriptions. Restricted cubic splines and Cox proportional hazard models estimated associations between BMI and incident mental illnesses. Mediation analyses assessed the mediating role of cardiometabolic disorders and biomarkers.

resultsThe study population included 10,465,562 adults (mean BMI 26.8 kg/m

conclusionsIndividuals with severe obesity and underweight had increased risk of common and serious mental illnesses, especially in women, younger individuals, and Asian populations. Associations were not mediated by cardiometabolic diseases but partially by biomarkers.

Indexed as

AdiposityMental DisordersObesityAdolescentAdultAgedBody Mass IndexCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsUnited KingdomYoung AdultAnxietyBody mass indexDepressionEating disorderLongitudinalSerious mental illness

Identifiers

PMID41316156
PMCPMC12763996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.