Evidence map›Paper›PMID 41316059›Full record

ArticleBMC infectious diseases2025

Association of Toll-like receptor signaling molecule gene polymorphisms with risk of cervical lesions in HPV-infected women.

Sutong Wang, Chunlin Zhang, Ting Li, Ping Luo, Yang Yang, Zicong Lin, Bing Mei

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PubMed Full text at PMC Publisher
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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Impact ofInternational journal of molecular sciences · 2026
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sutong WangDepartment of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434020, China.
Chunlin ZhangDepartment of Laboratory Medicine, Ezhou Central Hospital, Ezhou, Hubei, 436000, China.
Ting LiDepartment of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434020, China.
Ping LuoDepartment of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434020, China.
Yang YangDepartment of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434020, China.
Zicong LinDepartment of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434020, China.
Bing MeiDepartment of Laboratory Medicine, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, 434020, China. meibing008@163.com.

Funding

Key research and development plan project supporting local special funds in the field of comprehensive health of Hubei Province 2022BCE029Science and technology plan project of Jingzhou City 2022HC62
6 · The paper itself

Abstract

backgroundToll-like receptor signaling molecules are involved in tumor associated inflammatory response. This study aims to investigate the role of Toll-like receptor signaling molecule gene polymorphisms in the risk of HPV-related cervical lesions.

methodsA total of 352 study subjects, 178 women with cervical lesions and 174 women without cervical lesion were involved in a case-control study. Real-time polymerase chain reaction (real-time PCR) was used to detect HR-HPV genotypes. Genotyping of SNPs for MYD88 gene (rs7744) and TRAF3 gene (rs1131877, rs12435483, rs3803286, rs12147254) were performed by Sanger sequencing. The MYD88 and TRAF3 haplotype frequencies were analyzed using the HaploView 4.2 program. Gene-gene interactions were analyzed using the multifactor dimensionality reduction (MDR).

resultsThe TRAF3 rs3803286 (A) variant allele (OR = 0.724, p = 0.045) and TRAF3 rs1131877 (TC) variant genotype (OR = 0.563, p = 0.023) were found to be associated with a significantly reduced risk of cervical lesions. rs3803286-HPV-16/18 was the best interaction model for the risk of cervical lesions (p = 0.0004).

conclusionTRAF3 rs3803286 and rs1131877 are potential biomarkers of susceptibility to cervical lesions. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Human Papillomavirus VirusesMyeloid Differentiation Factor 88Papillomavirus InfectionsPolymorphism, Single NucleotideTNF Receptor-Associated Factor 3Uterine Cervical NeoplasmsAdultCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMiddle AgedPapillomaviridaeMYD88 protein, humanMyeloid Differentiation Factor 88TNF Receptor-Associated Factor 3TRAF3 protein, humanCervical cancerHPVSingle-nucleotide polymorphismsToll-like receptor signaling molecule

Identifiers

PMID41316059
PMCPMC12664277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.