SynthesisBMC infectious diseases2025
Prognostic factors of sepsis: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of the prognostic nutritional index in sepsis, pneumonia, and tuberculosis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Activity and Outcomes of a Multidisciplinary Sepsis Unit: Fifty Thousand Consultations over Thirteen Years.Antibiotics (Basel, Switzerland) · 2026Article
- Association of Circulating C-C Motif Chemokine Ligand 4 to Disease Severity and Clinical Outcomes in Sepsis: A Prospective Observational Study.Biomedicines · 2026Article
- Article
- The incremental prognostic value of platelet-to-neutrophil and platelet-to-lymphocyte ratios in patients with sepsis: A retrospective cohort study.The Journal of international medical research · 2026Article
- A Simple Admission-Based Score for Early Mortality Risk Stratification in Non-Shock Sepsis: A Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Article
- Intracellular ATP Levels in CD4Journal of inflammation research · 2026Article
- Machine Learning-Based Prediction of 28-Day Mortality in Patients with Sepsis-Induced Cardiomyopathy: An Integrated Analysis of Inflammatory Biomarkers.Journal of inflammation research · 2026Article
- Association of CD16Journal of inflammation research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveThis study aimed to systematically identify and evaluate prognostic risk factors for 30-day mortality in patients with sepsis through a meta-analysis.
methodsChinese and English databases were comprehensively searched from the start of the study to January 2025. Observational studies reporting multi-variable adjusted risk ratios (HRS) for prognostic factors of sepsis in adults were included. Data extraction and quality assessment using the Newcastle-Ottawa Scale were performed independently by two reviewers. Meta-analysis was performed using RevMan 5.4.1, and effect estimates were summarized using fixed or random effects models based on heterogeneity.
resultsTwenty studies involving 69 potential factors were included. A meta-analysis was performed on 15 factors. Increase in age (HR: 1.01), acute kidney injury (HR: 1.48), cancer (HR: 1.21), liver disease (HR: 1.58), septic shock (HR: 2.22), APACHE II (HR: 1.06), SOFA (HR: 1.19), SAPS II score (HR: 1.02), lactate (HR: 1.07) and red blood cell distribution width (HR: 1.07) were significant risk factors. Diabetes (HR: 0.80) and urinary tract infection (HR: 0.47) were protective factors. A high degree of heterogeneity was observed in some factors.
conclusionsMultiple factors have a significant impact on the mortality of sepsis. Early identification of these risk factors can guide clinical intervention strategies and improve patient outcomes.
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