Evidence map›Paper›PMID 41316011›Full record

ArticleBMC medical imaging2025

Differentiating medullary thyroid carcinoma from papillary thyroid carcinoma using ultrasound viscosity imaging: a preliminary study.

Qianru Zhang, Wei Zhou, Shangyan Xu, Siqi Hua, Ronghui Wang, Zhifang Yang, Jianqiao Zhou, Lili Gao, Weiwei Zhan

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Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Qianru ZhangDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei ZhouDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shangyan XuDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Siqi HuaDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ronghui WangDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhifang YangDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jianqiao ZhouDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lili GaoDepartment of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. gaolili_510@163.com.
Weiwei ZhanDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. shanghairuijinus@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the clinical feasibility of ultrasound viscosity imaging in the differential diagnosis of medullary thyroid carcinoma (MTC), aiming to provide more precise diagnostic tools and to support optimized treatment decisions and personalized clinical management in clinical practice.

methodsThe study included patients diagnosed with MTC and PTC (papillary thyroid carcinoma) at Shanghai Ruijin Hospital between March 2024 and December 2024. Quantitative analysis was performed for ultrasound viscosity imaging of thyroid carcinoma. Statistically significant indicators were screened and their diagnostic performance was evaluated.

resultsA total of 35 MTC patients with 35 MTC nodules and 45 PTC patients with 45 PTC nodules were finally enrolled. Various ultrasound viscosity imaging features demonstrated statistically significant value for differentiating MTC. Among them, S1-Vsd (viscosity standard deviation under the Visco mode with Shell = 1.0 mm) exhibited the best diagnostic performance with an AUC (area under the curve) of 0.70, which is superior to conventional ultrasound ACR-TIRADS (AUC = 0.63).

conclusionUltrasound viscosity imaging shows promising potential in enhancing the diagnostic accuracy of thyroid carcinoma, providing valuable support in differentiating MTC from PTC.

Indexed as

Carcinoma, NeuroendocrineThyroid Cancer, PapillaryThyroid NeoplasmsAdultDiagnosis, DifferentialFemaleHumansMaleMiddle AgedPreliminary DataUltrasonographyViscosityMedullary thyroid carcinomaPapillary thyroid carcinomaUltrasound viscosity imaging

Identifiers

PMID41316011
PMCPMC12752074

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