Evidence map›Paper›PMID 41316006›Full record

ArticleBMC pregnancy and childbirth2025

Association of maternal VDR and VDBP gene polymorphisms with spontaneous preterm birth risks: a nested case-control study in China.

Nana Li, Mengling Zhou, Lu Li, Yuting Li, Meixian Wang, Ying Deng, Yanping Wang, Jun Zhu, Shu Zhou, Ping Yu

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Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Nana LiNational Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China.
Mengling ZhouDepartment of Gynecology and Obstetrics, Chengdu Shuangliu District Maternal and Child Health Hospital, Chengdu, Sichuan, China.
Lu LiNational Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China.
Yuting LiNational Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China.
Meixian WangNational Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China.
Ying DengNational Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China.
Yanping WangNational Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China.
Jun ZhuNational Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China.
Shu ZhouKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China. zhoushu_1109@163.com.
Ping YuNational Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Sec.3 No.17, South RenMin Road, Chengdu, Sichuan, China. yup@scu.edu.cn.

Funding

National Key Research and Development Program of China 2022YFC2703700, 2022YFC2703702National Key Research and Development Program of China, 2022YFC2703300, 2022YFC2703302
6 · The paper itself

Abstract

backgroundThe impact of vitamin D on spontaneous preterm birth (SPTB) is still not well understood. This study aimed to explore the relationship between maternal vitamin D receptor (VDR) and vitamin D-binding protein (VDBP) gene polymorphisms, as well as gene-gene interactions, and their potential association with the risks of SPTB.

methodsA nested case-control study involving 200 pregnant women with SPTB and 199 controls with full-term delivery was performed. A total of eight maternal single nucleotide polymorphisms (SNPs) were genotyped, including those in the VDR gene at the rs731236, rs7975232, rs1544410, rs2228570, rs10783219, and rs11568820 loci, as well as those in the VDBP gene at the rs4588 and rs7041 loci. The multivariate logistic regressions were used to estimate the association between VDR and VDBP gene polymorphisms, including alleles, genotypes and haplotypes, and the risks of SPTB. Generalized multifactor dimensionality reduction (GMDR) was used to identify gene–gene interactions.

resultsAmong eight SNP loci, none of the minor alleles showed a significant association with the risks of SPTB. Additionally, the variant genotypes of these eight SNPs were not associated with the risks of SPTB under additive, dominant, and recessive genetic patterns. Moreover, three haplotypes in VDR gene and three haplotypes in VDBP gene were identified, but none of them demonstrated a significant association with the risks of SPTB. Lastly, no significant gene-gene interactions among the different SNPs were found to influence the risks of SPTB.

conclusionsCommon maternal polymorphisms in the VDR and VDBP genes were not significantly associated with the risks of SPTB, and no significant gene-gene interactions related to SPTB were observed.

Indexed as

Polymorphism, Single NucleotidePremature BirthReceptors, CalcitriolVitamin D-Binding ProteinAdultCase-Control StudiesChinaEpistasis, GeneticFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLogistic ModelsPregnancyRisk FactorsReceptors, CalcitriolVDR protein, humanVitamin D-Binding ProteinHaplotypesInteractionsPolymorphismsSpontaneous preterm birthVDBPVDR

Identifiers

PMID41316006
PMCPMC12763941

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.