ArticleBMC medical imaging2025
Correlation analysis of
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
Funding
Abstract
objectiveThis study aims to explore the correlation between 11C-CFT PET/CT imaging parameters and clinical characteristics of PD patients.
methodsThis study retrospectively included 69 PD patients and 10 healthy controls who had undergone 11C-CFT imaging to analyze the correlation between 11C-CFT imaging parameters and clinical features. The PD patients were divided into TD and PIGD groups based on the TD/PIGD score ratio, and H-Y stage 1–2 and H-Y stage 2.5-3 groups according to the H-Y stage. The differences in 11C-CFT parameters were compared between the groups.
resultsAfter FDR correction for 160 statistical tests, a strong negative correlation was identified between age and both the volume (r = -0.471, q < 0.01) and surface area (r = -0.474, q < 0.01) of the caudate nucleus. While several correlations between imaging parameters and clinical scores (e.g., UPDRS, bradykinesia) were observed at the nominal significance level (uncorrected P < 0.05), none of these associations remained statistically significant after FDR correction.
conclusionsThe most robust finding of this study is a significant age-related decline in caudate nucleus morphology in early to mid-stage PD. After rigorous statistical correction for multiple comparisons, no other significant correlations were found between dopaminergic PET/CT parameters and clinical scores.
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