ArticleBMC plant biology2025
Assembly and comparative analysis of chromosomal mitochondrial genomes in multiple Medicago species.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- TheGenes · 2026Article
- Complete mitochondrial genomes of the two high-valued bromeliads: comparative genomics and evolutionary insights.BMC genomics · 2026Article
- Mitogenome ofInternational journal of molecular sciences · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundMedicago is an economically important forage genus widely distributed across China, yet its mitochondrial genomes remain poorly understood. Comprehensive characterization of mitochondrial genome structure, function, and evolution is crucial for elucidating plant biological mechanisms, improving germplasm utilization, and advancing molecular breeding.
resultsWe assembled and compared the mitochondrial genomes of eight Medicago species, including six newly sequenced genomes. Five species contained typical single circular mitochondrial genomes, whereas M. falcata, M. platycarpos, and M. sativa displayed complex multipartite circular conformations. Genome sizes ranged from 281,240 to 356,577 bp, with 55-74 functional genes. Repeat analysis identified 141 simple sequence repeats (SSRs) and 76 tandem repeats (TSRs), largely composed of A/T-rich mononucleotide motifs, while dispersed repeats were mainly 30-49 bp in length. Codon usage showed a strong A/T bias and a preference for leucine, serine, and isoleucine. RNA editing events were predominantly C-to-U substitutions, primarily occurring at the first and second codon positions. Phylogenetic reconstruction based on 31 shared mitochondrial protein-coding genes (PCGs) strongly supported the monophyly of Medicago and recovered interspecific relationships consistent with previous chloroplast and nuclear genome studies. Most PCGs were under purifying selection, while a few, such as matR, exhibited signatures of positive selection, suggesting lineage-specific adaptive evolution.
conclusionsThis study expands the mitochondrial genomic resources of Medicago and provides new insights into its structural evolution and phylogenetic relationships, offering a valuable foundation for evolutionary and functional studies in Fabaceae.
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