SynthesisScientific reports2025
Natural antioxidant substances improve oxidative stress and alleviate ulcerative colitis: a meta-analysis of randomized controlled trials.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Preparation and Characterization of Rice Bran Protein Hydrolysates Enhanced via Alcalase andNutrients · 2026Article
- Activation of the Nrf2 Signaling Pathway by a Ginseng-Salvia Root-Notoginseng Composite Alleviates Ulcerative DSS-Induced Colitis via Restoring Gut Microbiota and the Intestinal Barrier.Antioxidants (Basel, Switzerland) · 2026Article
- Article
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Authors and funding
3 authors.
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Abstract
Oxidative stress is a key driver of mucosal damage in ulcerative colitis (UC). Antioxidant supplementation may restore redox balance, but its clinical efficacy remains controversial. To evaluate the effects of natural antioxidant substances supplementation on oxidation/antioxidant biomarkers and clinical outcomes in UC patients. The databases included PubMed, Embase, Web of Science, and Cochrane Library (up to July 2025) were searched, and RCTs comparing oral antioxidants with placebo in UC were included. The primary outcomes were changes in oxidative stress markers (MDA, SOD, TAC, GPX). The secondary outcomes included the short IBD questionnaire (SIBDQ) score and the simple clinical colitis activity index (SCCAI) score. 9 articles involving 624 patients were included in this study. Compared to placebo group, antioxidant substances supplementation could significantly reduce the level of MDA (P = 0.001, SMD=-1.09, 95% CI -1.75 to -0.43), increased the levels of SOD, TAC, GPX in patients with UC (P = 0.02, SMD = 0.57, 95% CI 0.10 to 1.04; P = 0.0004, SMD = 0.74, 95% CI 0.33 to 1.16; P = 0.004, SMD = 0.69, 95% CI 0.22 to 1.16). In addition, antioxidant substances supplementation remarkably decreased the SCCAI score of UC patients (P = 0.04, SMD=-0.62, 95% CI -1.21 to -0.04), thus improving the disease activity. However, there is no significant difference in the change of IBDQ score (P = 0.13, SMD = 0.55, 95% CI -0.17 to 1.28). Natural antioxidant substances supplementation effectively enhanced antioxidant capacity and ameliorated oxidation status, improved the disease activity of UC patients, but had no significant impact on their quality of life. This study will provide a basis for the selection of adjuvant therapy drugs for UC.
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Registered trials
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