Evidence map›Paper›PMID 41315851›Full record

ArticleCommunications biology2025

N-palmitoyl glycine differentially modulates TRPM4 and TRPC5 and is causally linked to Brugada syndrome.

Hongxuan Xu, Bingxun Li, Ying Chen, Yanyun Lin, An Zhang, Lin Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongxuan Xu *Department of Cardiology, Peking University First Hospital, Beijing, China.
Bingxun Li *Department of Cardiology, Peking University First Hospital, Beijing, China.
Ying ChenDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Yanyun LinDepartment of Cardiology, Peking University First Hospital, Beijing, China.
An ZhangDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Lin WuDepartment of Cardiology, Peking University First Hospital, Beijing, China. wuepgroup@126.com.ORCID http://orcid.org/0000-0001-6493-0125

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81930105National Natural Science Foundation of China (National Science Foundation of China) 82370312
6 · The paper itself

Abstract

Brugada syndrome (BrS) is an inherited cardiac arrhythmic disorder associated with an increased risk of malignant ventricular arrhythmia and sudden death. Mendelian randomisation implicated N-palmitoyl glycine (PalGly) in BrS risk and identified BrS-associated proteins (DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA), for which molecular docking further predicted moderate binding affinities with PalGly. PalGly enhanced calcium sparks in ventricular cardiomyocytes without affecting Na

Indexed as

Brugada SyndromeGlycineTRPC Cation ChannelsTRPM Cation ChannelsAnimalsHumansMaleMyocytes, CardiacRabbitsGlycineTRPC5 protein, humanTRPC Cation ChannelsTRPM4 protein, humanTRPM Cation Channels

Identifiers

PMID41315851
PMCPMC12753829

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.