Evidence map›Paper›PMID 41315638›Full record

ArticleScientific reports2025

Cone snail venom-inspired somatostatin receptor 4 (SSTR

Walden E Bjørn-Yoshimoto, Iris Bea L Ramiro, Thomas Lund Koch, Ebbe Engholm, Ho Yan Yeung, Kasper K Sørensen, Carolyn M Goddard, Kathrine L Jensen, Nicholas A Smith, Laurent F Martin and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Advances in Cyclic Peptides Targeting G Protein-Coupled Receptors.Chembiochem : a European journal of chemical biology · 2026
    Review
  4. Toxins in disguise: Neuropeptide mimicry across animal venoms.General and comparative endocrinology · 2026
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Walden E Bjørn-YoshimotoDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen-N, Denmark. walden@sund.ku.dk.
Iris Bea L RamiroDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen-N, Denmark.
Thomas Lund KochDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen-N, Denmark.
Ebbe EngholmDepartment of Chemistry, University of Copenhagen, Frederiksberg, Denmark.
Ho Yan YeungDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen-N, Denmark.
Kasper K SørensenDepartment of Chemistry, University of Copenhagen, Frederiksberg, Denmark.
Carolyn M GoddardDepartment of Neuroscience, University of Copenhagen, Copenhagen-N, Denmark.
Kathrine L JensenDepartment of Neuroscience, University of Copenhagen, Copenhagen-N, Denmark.
Nicholas A SmithLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.
Laurent F MartinDepartment of Anesthesiology and Pharmacology, University of Arizona, Tucson, AZ, USA.
Brian J SmithLa Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.
Kenneth L MadsenDepartment of Neuroscience, University of Copenhagen, Copenhagen-N, Denmark.
Knud J JensenDepartment of Chemistry, University of Copenhagen, Frederiksberg, Denmark.
Amol PatwardhanDepartment of Anesthesiology and Pharmacology, University of Arizona, Tucson, AZ, USA.
Helena Safavi-HemamiDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen-N, Denmark. helena.safavi@utah.edu.

Funding

Validation of Spinal Neurotensin Receptor 2 as an Analgesic TargetR01NS116694 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PATWARDHAN, AMOL M · 2020 to 2025
$2.0M
Mechanism of intrathecal Contulakin-G induced analgesia without motor blockK08NS104272 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PATWARDHAN, AMOL M · 2018 to 2022
$987k
Danmarks Frie Forskningsfond 3102-00006Lundbeck Foundation R322-2019-1816Lundbeck Foundation R344-2020-106Lundbeck Foundation R400-2022-509NIH HHS R01NS116694NINDS NIH HHS K08 NS104272NINDS NIH HHS R01 NS116694Villum Fonden 19063
6 · The paper itself

Abstract

Persistent pain affects one in five people worldwide, often with severely debilitating consequences. While current treatments can be effective for mild or acute pain, they are largely inadequate for managing moderate to severe chronic pain, underscoring the urgent need for new therapeutics. The somatostatin receptor 4 (SSTR

Indexed as

AnalgesicsConus SnailMollusk VenomsNeuralgiaReceptors, SomatostatinAnimalsDisease Models, AnimalHumansMaleMiceStructure-Activity RelationshipAnalgesicsMollusk VenomsReceptors, Somatostatinsomatostatin receptor subtype-4

Identifiers

PMID41315638
PMCPMC12663243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.