Evidence map›Paper›PMID 41315613›Full record

ArticleScientific reports2025

Threshold-distance functions predict speech recognition with cochlear implants.

E Kludt, S Ewald, N Prenzler, R Salcher, K Willenborg, M Sato, A Büchner, A Kral, T Lenarz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

E KludtClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany. kludt.eugen@mh-hannover.de.
S EwaldClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
N PrenzlerClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
R SalcherClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
K WillenborgClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
M SatoClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
A BüchnerClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
A KralClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.
T LenarzClinics of Otolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cochlear implantation shows unexplained outcome variability. Among the key factors affecting outcomes measured by speech understanding is the functional state of the auditory nerve and the amount of its degeneration due to hearing loss. In the present study we actively varied the distance of the stimulating electrodes from the modiolus (the spiral ganglion), quantified it using fluoroscopy and cone-beam computed tomography and related it to electrically-evoked compound action potentials (eCAPs) in human subjects. Stimulation was monopolar. The distance from modiolus could explain up to 91% of the variability in the thresholds of eCAPs. The threshold varied between participants. For individual electrodes of the implant in the given participant, a linear relationship between threshold (in current level) and distance from modiolar axis was found, with different slopes in different participants. The slopes of the eCAP thresholds to modiolus distance of the electrode across ears could explain up to 67% of the variability of speech understanding in these participants. We suggest that the slope of the threshold-distance function might serve as a marker for the functional state of the target neurons (spiral ganglion cells) and can be used to assess this in individual subjects.

Indexed as

Auditory ThresholdCochlear ImplantsSpeech PerceptionAction PotentialsAdultAgedCochlear ImplantationCochlear NerveCone-Beam Computed TomographyElectric StimulationEvoked Potentials, AuditoryFemaleHumansMaleMiddle AgedYoung AdultAuditory nerve degenerationCochlear healthCompound action potentialsNeuronal survivalPull-back technique

Identifiers

PMID41315613
PMCPMC12673073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.