ArticleScientific reports2025
Abnormal glycosylation changes in brain tissue of kainic acid-induced epileptic rats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- AAV-mediated GPR173 gene therapy attenuates long-term refractory epilepsy by enhancing synaptic GABAActa pharmacologica Sinica · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Despite significant progress in epilepsy research, about 30% of patients continue to experience uncontrolled seizures and clear diagnostic criteria remain elusive. Abnormal glycosylation contributes to various neurological disorders, including Alzheimer's and Parkinson's diseases. However, it is unclear whether protein glycosylation is altered in epilepsy. Herein, we established a chronic epilepsy rat model by injecting kainic acid solution into the right lateral ventricle and examined the changes in protein N-glycosylation and O-GlcNAcylation in rat brain tissues using mass spectrometry and lectin blotting. We found a significant reduction in complex N-glycan abundance in the hippocampal tissue of epileptic rats, which may be related to decreased MGAT1 expression. Additionally, we observed a marked decrease in protein O-GlcNAcylation, which may be associated with reduced levels of GFPT1, the rate-limiting enzyme in the hexosamine biosynthesis pathway. This research offers new insight into potential therapeutic strategies for epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.