ArticleCommunications biology2025
A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Survey of nucleotide-specific Rab GTPase interactions reveals multiple Rab effectors.bioRxiv : the preprint server for biology · 2026Article
- Proteomic investigation of signaling dynamics: from static maps to network rewiring.Bioscience reports · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
RAB GTPases, the most abundant small GTPase family, regulate membrane trafficking, including cargo sorting, vesicle budding, transport, docking, and fusion. Guanine exchange factors and GTPase-activating proteins control their activity. Activated RABs recruit effectors to mediate trafficking, but identifying RAB-associated proteins is challenging due to the transient nature of their interactions. Recent proximity labeling techniques enable covalent tagging of nearby proteins, allowing for comprehensive mapping of RAB GTPases neighboring proteins. Here we report APEX2 proximity labeling of 23 human RABs and their neighboring proteomes. Bioinformatic analyses revealed proximal proteins for a broad range of RABs. Notably, we identified a novel interaction between RAB25 and DENND6A, with RAB25 overexpression promoting DENND6A recruitment to recycling endosomes. We also uncovered functional links between RAB14 and the EARP complex, as well as SHIP164 and its ortholog UHRF1BP1. Our dataset offers a valuable resource for exploring new functional connections between RAB GTPases and their associated proteins.
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