Evidence map›Paper›PMID 41315355›Full record

ArticleNature communications2025

Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in hidradenitis suppurativa skin disease.

Kaitlin L Williams, Beita Badiei, James Reilly, William Andrews, Hana B Minsky, Nina Rossa Haddad, Eddie G Martinez Pena, Mengqi Sun, Sam Lee, Ang Li and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kaitlin L WilliamsDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8768-0488
Beita BadieiDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0009-0009-4183-9383
James ReillyDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
William AndrewsDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Hana B MinskyDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8038-4646
Nina Rossa HaddadDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eddie G Martinez PenaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4545-7154
Mengqi SunDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sam LeeDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3760-8960
Ang LiDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Leigh Curvin-AquillaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Arieana Y JohnsonDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0009-0006-3869-8581
Aiden WillisDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charles S KirbyDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Amy van EeDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-1277-3137
Yingchao XueDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Carrie A CoxDepartment of Plastic and Reconstructive surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shanmuga Priya RajagopalanDepartment of Plastic and Reconstructive surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4096-9740
Sewon KangDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kurunthachalam KannanWadsworth Center, New York State Department of Health, Albany, NY, USA.
Julie CaffreyDepartment of Plastic and Reconstructive surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nathan K ArcherDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8212-8985
Maureen KaneDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5525-9170
Luis A GarzaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. LAG@jhmi.edu.ORCID http://orcid.org/0000-0002-6547-9695

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Retinoic acid synthesis induced by noncoding dsRNA controls RegenerationR01AR074846 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2019 to 2023
$2.3M
Inhibition of regeneration restraining pathways to promote healingR01AR083822 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Luis Andres Garza · 2025 to 2026
$1.3M
Inhibition of Regeneration Restraining Pathways to Promote HealingR56AR082660 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2023 to 2023
$360k
NIAMS NIH HHS R01 AR074846NIAMS NIH HHS R01 AR083822NIAMS NIH HHS R56 AR082660NIGMS NIH HHS T32 GM136577U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR074846U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR083822
6 · The paper itself

Abstract

Hidradenitis Suppurativa (HS) is an inflammatory skin disorder with limited treatments and unclear etiology. While monogenic HS is linked to gamma secretase mutations, particularly in the NCSTN subunit, the pathogenesis of the more common sporadic form remains uncertain, though associated with risk factors such as diets high in ultra-processed foods. Consistent with the clinical overlap between sporadic and monogenic HS, we find loss of NCSTN protein in sporadic HS fibroblasts. We hypothesize the rising incidence of sporadic HS and its hormonal associations implicate endocrine-disrupting chemicals, especially plastic-associated EDCs (p-EDs) common in UPFs. We detect elevated p-ED adducts in HS skin, persisting in ex vivo cultured fibroblasts. At nanomolar concentrations, p-EDs inhibits NCSTN and primes fibroblasts for inflammation, mimicking NCSTN knockdown. These findings suggest p-ED exposure contributes to HS pathogenesis, highlighting the need to address environmental exposures in HS and other gamma secretase-related diseases.

Indexed as

Amyloid Precursor Protein SecretasesEndocrine DisruptorsHidradenitis SuppurativaInflammationMembrane GlycoproteinsAdultCells, CulturedFemaleFibroblastsHumansMaleSkinAmyloid Precursor Protein SecretasesEndocrine DisruptorsMembrane Glycoproteinsnicastrin protein

Identifiers

PMID41315355
PMCPMC12663211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.