Evidence map›Paper›PMID 41315334›Full record

ArticleNature communications2025

Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure.

Rasha Shraim, Maria Timofeeva, Cathy Wyse, Jos van Geffen, Michiel van Weele, Roman Romero-Ortuno, Lorna M Lopez, Marcus E Kleber, Stefan Pilz, Winfried März and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rasha ShraimDepartment of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-3351-1179
Maria TimofeevaMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2503-4253
Cathy WyseDepartment of Biology, Maynooth University, Kildare, Ireland.
Jos van GeffenRoyal Netherlands Meteorological Institute, 3731, GA De Bilt, The Netherlands.ORCID http://orcid.org/0000-0003-2121-4553
Michiel van WeeleRoyal Netherlands Meteorological Institute, 3731, GA De Bilt, The Netherlands.
Roman Romero-OrtunoDiscipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-3882-7447
Lorna M LopezDepartment of Biology, Maynooth University, Kildare, Ireland.ORCID http://orcid.org/0000-0002-0241-9783
Marcus E KleberSYNLAB MVZ für Humangenetik, Mannheim, Germany.ORCID http://orcid.org/0000-0003-0663-7275
Stefan PilzDepartment of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.
Winfried MärzSYNLAB MVZ für Humangenetik, Mannheim, Germany.
Benjamin S FletcherCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.ORCID http://orcid.org/0009-0000-9986-5677
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.ORCID http://orcid.org/0000-0001-5751-9178
Evropi TheodoratouCancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5887-9132
Malcolm G DunlopMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3033-5851
Ross McManusDepartment of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-0529-9617
Lina ZgagaDepartment of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, Dublin, Ireland. zgagal@tcd.ie.ORCID http://orcid.org/0000-0003-4089-9703

Funding

Cancer Research UK (CRUK) C31250/A22804Cancer Research UK (CRUK) DRCPGM\100012EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 950010Science Foundation Ireland (SFI) 18/CRT/6214Science Foundation Ireland (SFI) 18/FRL/6188
6 · The paper itself

Abstract

Vitamin D status is influenced by genetic and environmental factors-primarily sun exposure. Using satellite weather data, we estimated an ambient UVB dose for each participant based on residential address and date of sampling. We conducted genome-wide tests in 338,977 UK Biobank White British participants, adjusted for age, sex, supplements, UVB dose, and 10 principal components to account for population structure. We applied three models to test for genetic effects: marginal only, main and interaction, and joint effects. We identified 307 variants associated with standardised log-transformed 25-hydroxyvitamin D (25OHD) concentration, 162 of which were not previously identified in GWAS. We identify an increase in SNP-heritability by increasing ambient UVB exposure quintiles (h

Indexed as

Gene-Environment InteractionUltraviolet RaysVitamin DAdultAgedCircadian RhythmFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideSeasonsSunlightUnited Kingdom25-hydroxyvitamin DVitamin D

Identifiers

PMID41315334
PMCPMC12663108

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.