ArticleNature communications2025
Pyridinium ylides as photocatalytic atom transfer reagents.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Conversion of Alkenes Into Simple or Functionalized Aldehydes by Reaction With an Ambiphilic Masked Formyl Radical.Angewandte Chemie (International ed. in English) · 2026Article
- Unlocking congested 3D molecular architectures for drug discovery.Nature chemistry · 2026Article
- Modular diastereoselective synthesis of hindered cyclobutane amino nitriles through triplet nitrene-mediated ring expansion.Nature chemistry · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The selective incorporation of single atoms into molecular frameworks remains a fundamental challenge in synthetic chemistry. While atom transfer reactions offer promising solutions, they require reagents with precisely tunable reactivity and excellent chemoselectivity. Herein, we report pyridinium ylides as photocatalytic oxygen atom and nitrogen group transfer reagents that combine a unique reaction mode with practical advantages including bench stability and operational simplicity. These ylides form reactive triplet diradicals via reversible photocatalytic activation, enabling selective formation of aziridines, epoxides, and oxo- and imino-transfer products at room temperature in open air. Their controlled reactivity allows selective transformations across diverse substrates, proving particularly valuable for late-stage functionalization. Mechanistic investigations combining experimental and computational methods reveal a triplet-triplet energy transfer pathway proceeding through a carbocation intermediate.
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Registered trials
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