Evidence map›Paper›PMID 41315304›Full record

ArticleScientific reports2025

Development and validation of combined in vitro and in vivo assays for evaluating the efficacy of strontium-chelating compounds.

Nóra Varga, Viola Pomozi, Eszter Kozák, Zsuzsa Erdei, Szilárd Tóth, Adriána Kutás, Zoltán Mucsi, Zsolt Rapi, Beatrix Kovács, Anett Matuscsák and 6 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nóra Varga *Creative Cell Ltd., Budapest, 1119, Hungary.
Viola Pomozi *Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary.
Eszter Kozák *Creative Cell Ltd., Budapest, 1119, Hungary.
Zsuzsa Erdei *Creative Cell Ltd., Budapest, 1119, Hungary.
Szilárd TóthInstitute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary.
Adriána KutásAdvanced Materials and Intelligent Technologies Higher Education and Industrial Cooperation Centre, University of Miskolc, Egyetemváros, C/2 épület 4.hajó dél I. 108., Miskolc, 3515, Hungary.
Zoltán MucsiAdvanced Materials and Intelligent Technologies Higher Education and Industrial Cooperation Centre, University of Miskolc, Egyetemváros, C/2 épület 4.hajó dél I. 108., Miskolc, 3515, Hungary.
Zsolt RapiDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, 1111, Hungary.
Beatrix KovácsInstitute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, 1117, Hungary.
Anett MatuscsákLaboratory of 3D Functional Network and Dendritic Imaging, HUN-REN Institute of Experimental Medicine, Szigony st 43., Budapest, 1083, Hungary.
Olivér BánhídiAdvanced Materials and Intelligent Technologies Higher Education and Industrial Cooperation Centre, University of Miskolc, Egyetemváros, C/2 épület 4.hajó dél I. 108., Miskolc, 3515, Hungary.
Csaba VáradiAdvanced Materials and Intelligent Technologies Higher Education and Industrial Cooperation Centre, University of Miskolc, Egyetemváros, C/2 épület 4.hajó dél I. 108., Miskolc, 3515, Hungary.
Tamás RáczStratoxer(s) Ltd., Várpalota, 8100, Hungary.
Katalin NémetCreative Cell Ltd., Budapest, 1119, Hungary.
Béla ViskolczAdvanced Materials and Intelligent Technologies Higher Education and Industrial Cooperation Centre, University of Miskolc, Egyetemváros, C/2 épület 4.hajó dél I. 108., Miskolc, 3515, Hungary. bela.viskolcz@uni-miskolc.hu.
Áron SzepesiLaboratory of 3D Functional Network and Dendritic Imaging, HUN-REN Institute of Experimental Medicine, Szigony st 43., Budapest, 1083, Hungary. aron.szepesi@outlook.hu.

Funding

The National Research, Development and Innovation Office, Hungary TKP2021NVA-14
6 · The paper itself

Abstract

The aim of this study is to develop a combined in vitro and in vivo assay for the comprehensive efficacy evaluation of strontium-chelating compounds. The complexation and removal of harmful radioactive strontium (

Indexed as

Chelating AgentsStrontiumAnimalsHumansMiceStrontium RadioisotopesChelating AgentsStrontiumStrontium RadioisotopesBone differentiationBone incorporation preventionRadioactive strontiumStrontium-chelating compounds

Identifiers

PMID41315304
PMCPMC12672587

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.