Evidence map›Paper›PMID 41315289›Full record

ArticleNPJ biofilms and microbiomes2025

MicroMap: a network visualisation resource for human microbiome metabolism.

Cyrille C Thinnes, Renee Waschkowitz, Eoghan Courtney, Eoghan Culligan, Katie Fahy, Ruby A M Ferrazza, Ciara Ferris, Angeline Lagali, Rebecca Lane, Colm Maye and 21 more

Abstract read
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Cyrille C ThinnesDigital Metabolic Twin Centre, University of Galway, Galway, Ireland.
Renee WaschkowitzDigital Metabolic Twin Centre, University of Galway, Galway, Ireland.
Eoghan CourtneyUniversity College Dublin, Dublin, Ireland.
Eoghan CulliganUniversity College Dublin, Dublin, Ireland.
Katie FahyUniversity of Galway, Galway, Ireland.
Ruby A M FerrazzaUniversity of Galway, Galway, Ireland.
Ciara FerrisUniversity College Cork, Cork, Ireland.
Angeline LagaliUniversity College Cork, Cork, Ireland.
Rebecca LaneUniversity of Galway, Galway, Ireland.
Colm MayeUniversity College Cork, Cork, Ireland.
Olivia MurphyUniversity of Galway, Galway, Ireland.
David NooneUniversity of Galway, Galway, Ireland.
Saoirse RyanUniversity of Galway, Galway, Ireland.
Mihaela BetTrinity College Dublin, Dublin, Ireland.
Maria C CorrTrinity College Dublin, Dublin, Ireland.
Hannah CumminsUniversity of Galway, Galway, Ireland.
David HackettUniversity College Dublin, Dublin, Ireland.
Ellen HealyUniversity College Dublin, Dublin, Ireland.
Nina KulczyckaUniversity of Galway, Galway, Ireland.
Niall LangUniversity of Galway, Galway, Ireland.
Luke MaddenUniversity College Dublin, Dublin, Ireland.
Lynne McHughUniversity of Galway, Galway, Ireland.
Ivana PyneUniversity of Galway, Galway, Ireland.
Ciara VarleyUniversity of Galway, Galway, Ireland.
Niamh HarkinUniversity of Galway, Galway, Ireland.
Ronan MeadeUniversity of Galway, Galway, Ireland.
Grace O'DonnellUniversity of Galway, Galway, Ireland.
Bram NapDigital Metabolic Twin Centre, University of Galway, Galway, Ireland.
Filippo MartinelliDigital Metabolic Twin Centre, University of Galway, Galway, Ireland.
Almut HeinkenDigital Metabolic Twin Centre, University of Galway, Galway, Ireland.
Ines ThieleDigital Metabolic Twin Centre, University of Galway, Galway, Ireland. ines.thiele@universityofgalway.ie.

Funding

Project 4 - Mechanistic studies on the role of the gut microbiome in models for Alzheimer's diseaseU19AG063744 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Rima F Kaddurah-Daouk · 2019 to 2026
$54.1M
Gut Liver Brain Biochemical Axis in Alzheimer's DiseaseRF1AG058942 · NIA · DUKE UNIVERSITY · PI KADDURAH-DAOUK, RIMA F, VAN DUIJN, CORNELIA MARJA · 2018 to 2018
$3.4M
European Research Council 757922H2020 Marie Skłodowska-Curie Actions 859890NIA NIH HHS RF1 AG058942NIA NIH HHS U19 AG063744NIH HHS 1RF1AG058942Science Foundation Ireland 12/RC/2273-P2
6 · The paper itself

Abstract

The human microbiome critically influences metabolism and thereby our health. Constraint-based reconstruction and analysis (COBRA) is a proven framework for generating mechanism-derived hypotheses along the nutrition-host-microbiome-disease axis. However, no large-scale microbiome metabolism visualisation has been available. Therefore, we created the MicroMap, a manually curated network visualisation, which captures the metabolism of over a quarter million microbial genome-scale metabolic reconstructions. The MicroMap contains 5064 unique reactions and 3499 unique metabolites, including for 98 drugs. Users can intuitively explore microbiome metabolism, inspect metabolic capabilities, and visualise computational modelling results. Further, the MicroMap may serve as an educational tool to help diversify the computational modelling community. We generated 257,429 visualisations, covering all our current microbiome reconstructions, to visually compare metabolic capabilities between microbes. The MicroMap integrates with the Virtual Metabolic Human (VMH, www.vmh.life ), the COBRA Toolbox (https://opencobra.github.io ), and is freely accessible at the MicroMap dataverse ( https://dataverse.harvard.edu/dataverse/micromap ), along with all the generated reconstruction visualisations.

Indexed as

BacteriaComputational BiologyMetabolic Networks and PathwaysMicrobiotaSoftwareComputer SimulationHumans

Identifiers

PMID41315289
PMCPMC12663093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.