Evidence map›Paper›PMID 41315276›Full record

ArticleNature communications2025

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.

Bryan J Song, Yang Ge, Ally Nicolella, Min Jee Kwon, Bart Lodder, Kevin Bonanno, Antia Valle-Tojeiro, Nolan D Hartley, Kira Perzel Mandell, John Adeleye and 26 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Signaling architecture of the glucagon-like peptide-1 receptor.The Journal of clinical investigation · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Bryan J Song *The Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. bsong@broadinstitute.org.
Yang Ge *The Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ally NicolellaThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Min Jee KwonThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bart LodderDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0001-1733-1311
Kevin BonannoThe Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Antia Valle-TojeiroThe Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0004-3737-3916
Nolan D HartleyThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4340-3478
Kira Perzel MandellThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6262-6904
John AdeleyeThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Deeksha MisriThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Chuhan GengThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sahana NatarajanThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Inès PicardThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0002-5975-7473
Nate ShepardThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8629-3152
Alyssa HallThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jiawen TianThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sameer AryalThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3577-4383
Zohreh FarsiThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Xiao-Man LiuThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9968-3988
Nader MorshedThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0346-9651
Naeem M NadafThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7805-8523
Horia PribiagThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sean K SimmonsThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
D R ManiThe Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3914-133X
Beth StevensThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4226-1201
Prabhat S KunwarThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Zhanyan FuThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9473-2402
Evan Z MacoskoThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2794-5165
Joshua Z LevinThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0170-3598
Bernardo L SabatiniDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0095-9177
Steven A CarrThe Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7203-4299
Borislav DejanovicThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Hasmik KeshishianThe Proteomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Adam J GrangerThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. agranger@broadinstitute.org.
Morgan ShengThe Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. msheng@broadinstitute.org.ORCID http://orcid.org/0000-0002-8703-5366

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Action and Interaction of Neurotransmitters and NeuromodulatorsR35NS137336 · NINDS · HARVARD MEDICAL SCHOOL · PI Bernardo L Sabatini · 2024 to 2026
$2.1M
NICHD NIH HHS P50 HD105351NINDS NIH HHS R35 NS137336
6 · The paper itself

Abstract

Loss-of-function mutations in AKAP11 (a protein kinase A (PKA)-binding protein) greatly increase the risk of bipolar disorder and schizophrenia. To determine the neurobiological functions of AKAP11, we conduct multi-omic and neurobiological analyses of Akap11 mutant mouse brains. We find that AKAP11 is a key regulator of PKA proteostasis in the brain whose loss leads to dramatically increased levels of PKA subunits and phosphorylated PKA substrates, especially in synapses. Akap11 mutant mice show extensive transcriptomic changes throughout the brain, including prominent decreases in synapse-related genes sets. Gene expression is highly impacted in spiny projection neurons of the striatum, a brain region implicated in motivation, cognition and psychotic disorders. Real-time measurements of PKA activity reveal elevated basal PKA activity in the striatum of Akap11

Indexed as

A Kinase Anchor ProteinsBipolar DisorderCorpus StriatumCyclic AMP-Dependent Protein KinasesDopamineSchizophreniaSynapsesAnimalsDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMutationSignal TransductionA Kinase Anchor ProteinsCyclic AMP-Dependent Protein KinasesDopamine

Identifiers

PMID41315276
PMCPMC12663429

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.