Evidence map›Paper›PMID 41315264›Full record

ArticleNature communications2025

Gene therapy delivery of anti-Müllerian hormone in prepubertal female domestic cats induces long-term sterilization.

Philippe Godin, Nicholas Nagykery, Natalie Sicher, Julie L Barnes, Amy G Miller, Christina Bunner, Amy K Thompson, Motohiro Kano, Guangping Gao, Dan Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Philippe GodinPediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0857-6891
Nicholas NagykeryPediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
Natalie SicherPediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
Julie L BarnesCenter for Conservation and Research of Endangered Wildlife (CREW), Cincinnati Zoo and Botanical Garden, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-7314-2574
Amy G MillerCenter for Conservation and Research of Endangered Wildlife (CREW), Cincinnati Zoo and Botanical Garden, Cincinnati, OH, USA.
Christina BunnerCenter for Conservation and Research of Endangered Wildlife (CREW), Cincinnati Zoo and Botanical Garden, Cincinnati, OH, USA.
Amy K ThompsonCenter for Conservation and Research of Endangered Wildlife (CREW), Cincinnati Zoo and Botanical Garden, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-8611-4767
Motohiro KanoPediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
Guangping GaoHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-0097-9012
Dan WangHorae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0001-9079-2360
Patricia K DonahoePediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
Linda RhodesMichelson Found Animals Foundation Inc., Los Angeles, CA, USA.
David A BrakeMichelson Found Animals Foundation Inc., Los Angeles, CA, USA.
Thomas J ConlonMichelson Found Animals Foundation Inc., Los Angeles, CA, USA.
William F SwansonCenter for Conservation and Research of Endangered Wildlife (CREW), Cincinnati Zoo and Botanical Garden, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-4067-0319
Lindsey M VansandtCenter for Conservation and Research of Endangered Wildlife (CREW), Cincinnati Zoo and Botanical Garden, Cincinnati, OH, USA. lindsey.vansandt@cincinnatizoo.org.ORCID http://orcid.org/0000-0002-5951-2057
David PépinPediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA. dpepin@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-2046-6708

Funding

Harvard Clinical and Translational Science CenterUM1TR004408 · NCATS · HARVARD MEDICAL SCHOOL · PI Lindsey Robert Baden, Lee Marshall Nadler · 2023 to 2026
$43.3M
Fonds de Recherche du Québec - Nature et Technologies (Quebec Fund for Research in Nature and Technology) 313511Fonds de Recherche du Québec - Nature et Technologies (Quebec Fund for Research in Nature and Technology) 356514Michelson Prize and Grants (Michelson Prize & Grants) MG14-S06NCATS NIH HHS UM1 TR004408
6 · The paper itself

Abstract

The uncontrolled reproduction of free-roaming domestic cats exacerbates their welfare challenges and the ecological pressure they exert on wildlife populations. Because of logistic and economic constraints, surgical sterilization alone cannot scale to control the reproduction of the hundreds of millions of intact cats worldwide. Herein, we report that the single administration of an adeno-associated viral vector delivering an anti-Müllerian hormone transgene to prepubertal cats can fully prevent pregnancy once females reach adulthood. Treated kittens were closely monitored for up to 21 months to assess long-term health, transgene expression, reproductive hormones, and reproductive function. The intramuscular injection was well tolerated and did not impact physical growth. The sustained expression of anti-Müllerian hormone did not impact spermatogenesis in males. However, it induced sterility in mated females by preventing breeding-induced ovulation and increases in progesterone associated with luteal phases, resulting in safe and potentially lifetime sterilization in the female domestic cat.

Indexed as

Anti-Mullerian HormoneGenetic TherapySterilization, ReproductiveAnimalsCatsDependovirusFemaleGenetic VectorsMalePregnancyProgesteroneTransgenesAnti-Mullerian HormoneProgesterone

Identifiers

PMID41315264
PMCPMC12663202

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.