ArticleNature communications2025
Mechanisms of Pseudomonas aeruginosa resistance to type VI secretion system attacks.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- T6SS mutants exploit itaconate to support infection of phagocytes.bioRxiv : the preprint server for biology · 2026Article
- Type VI secretion system-mediated bacterial antagonism in the classroom.Access microbiology · 2026Article
- Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system.Cell host & microbe · 2025Article
- Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system.bioRxiv : the preprint server for biology · 2025Article
- Decoding resistance in the age of T6SS warfare.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The Type VI Secretion System (T6SS) is a molecular nanomachine that injects toxic effector proteins into the environment or neighboring cells, playing an important role in interbacterial competition and host antagonism during infection. Pseudomonas aeruginosa encodes three T6SSs. One of them, the H1-T6SS, delivers toxins in response to attacks mediated by the T6SS of aggressor bacteria, suggesting that P. aeruginosa can resist T6SS assaults. The mechanisms of resistance are poorly characterized. Here, we perform a CRISPRi screen to identify pathways involved in resistance to T6SS effectors of Acinetobacter baylyi ADP1 and Vibrio cholerae 2740-80. We show that members of the GacA/GacS regulon, such as the mag operon or aas, and GacA-independent factors, like the outer membrane protein OprF, confer resistance to different types of T6SS toxins. Interestingly, some of these T6SS protection mechanisms lead to higher antibiotic susceptibility, suggesting complex evolutionary links between T6SS and antibiotic resistance.
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Registered trials
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