ArticleTranslational psychiatry2025
MRI signature of brain age underlying post-traumatic stress disorder in World Trade Center responders.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Toward multimodal MRI biomarkers of PTSD: functional and structural connectivity signatures in WTC responders.medRxiv : the preprint server for health sciences · 2026Article
- Characteristic spatiotemporal features of large-scale functional network architecture in posttraumatic stress disorder.Translational psychiatry · 2026Article
- Occupational circadian disruption and brain structure: evidence from normative developmental brain lifespan trajectories.Brain structure & function · 2026Article
- Development and Validation of a Brain Aging Biomarker in Middle-Aged and Older Adults: Deep Learning Approach.JMIR aging · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
Approximately 23% of the men and women who participated in rescue and recovery efforts at the 9/11 World Trade Center (WTC) site experience persistent, clinically significant post-traumatic stress disorder (PTSD). Recent structural and functional magnetic resonance imaging (MRI) studies demonstrate significant neural differences between WTC responders with and without PTSD. Here, we used brain age, a novel MRI-based data-driven biomarker optimized to detect accelerated structural aging and examined the impact of PTSD on this process. Using BrainAgeNeX, a novel convolutional neural network that bypasses brain parcellation and has been trained and validated on over 11,000 T1-weighted MRI scans, we predicted brain age in WTC responders with PTSD (WTC-PTSD, n = 47) and age/sex matched responders without PTSD (non-PTSD, n = 52). Brain Age Difference (BAD) was then calculated for each WTC responder by subtracting chronological age from brain age. We found that BAD was significantly older in WTC-PTSD compared to non-PTSD responders (BAD
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