Evidence map›Paper›PMID 41315084›Full record

ArticleMolecular neurobiology2025

Proteome-Based Plasma Biomarkers for Cognitive Dysfunction in an Androgen Deprivation Model.

Vaibhav Singh, Shiv Verma, Eswar Shankar, Diya Swain, Belinda B Willard, Herta H Chao, Chiang-Shan R Li, Zhenghong Lee, Gregory T MacLennan, Lee E Ponsky and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vaibhav SinghDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Shiv VermaDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Eswar ShankarDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Diya SwainDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Belinda B WillardProteomics and Metabolomics Core, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Herta H ChaoDepartment of Medicine, Yale University School of Medicine, New Haven, CT, 06510, USA.
Chiang-Shan R LiDepartment of Psychiatry and of Neuroscience, Yale University School of Medicine, New Haven, CT, 06519, USA.
Zhenghong LeeDepartment of Radiology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Gregory T MacLennanDepartment of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Lee E PonskyDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA.
Sanjay GuptaDepartment of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA. sanjay.gupta@case.edu.

Funding

Neurocognitive Changes from Long-Term Androgen Deprivation Therapy in Prostate Cancer PatientsR01CA218501 · NCI · YALE UNIVERSITY · PI CHAO, HERTA HUEY-AN · 2018 to 2023
$1.9M
CSRD VA I01 CX001301NCI NIH HHS R01 CA218501NCI NIH HHS R01CA218501U.S. Department of Defense W81XWH-19-1-0720VA Merit Award 5I01CX001301-06
6 · The paper itself

Abstract

Cognitive dysfunction frequently arises from androgen deprivation therapy (ADT), a primary treatment for men with prostate cancer. ADT affects key cognitive functions like memory, learning, reasoning, and decision-making. Extant studies lack a systematic evaluation of biomarkers related to ADT's cognitive impact. To address this, we used nano-liquid chromatography tandem mass spectrometry (nLC-MS/MS) to identify biomarkers in specific brain regions of a mouse model. Sixteen-week-old BALB/c mice received enzalutamide, a nonsteroidal antiandrogen, at 50 mg/kg/day via oral gavage 5 days a week for 8 weeks to simulate the ADT protocol. Control mice received a comparable volume of the vehicle. Enzalutamide treatment resulted in modest weight gain along with behavioral changes, including attention deficits and reduced social activity.

Indexed as

Androgen AntagonistsAndrogensBiomarkersCognitive DysfunctionProteomeAnimalsBenzamidesBrainDisease Models, AnimalMaleMiceMice, Inbred BALB CNitrilesPhenylthiohydantoinAndrogen AntagonistsAndrogensBenzamidesBiomarkersenzalutamideNitrilesPhenylthiohydantoinProteomeAndrogen deprivation therapyAndrogen receptorCognitive dysfunctionEnzalutamideProteomics

Identifiers

PMID41315084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.