Evidence map›Paper›PMID 41314942›Full record

Observational studyBritish journal of anaesthesia2026

Association between obstructive sleep-disordered breathing severity and pain trajectories after adenotonsillectomy in children: a prospective cohort study.

Chantal Frigon, Ramanakumar V Agnihotram, Annick Bérard-Giasson, Frederic Lamonde, Menglan Pang, Sam J Daniel, Karen A Brown

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03378830 (Pain at Home After Tonsillectomy With or Without Adenoidectomy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03378830 completednot on this map

Pain at Home After Tonsillectomy With or Without Adenoidectomy

TypeobservationalSponsorMcGill University Health Centre/Research Institute of the McGill University Health CentreRan2017 to 2019Enrolled319ConditionsSleep Apnea, Adenotonsillectomy, Pediatric ALL
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Chantal FrigonDepartment of Anaesthesia, Division of Paediatric Anaesthesia, McGill University, Montreal, QC, Canada.
Ramanakumar V AgnihotramResearch Institute of McGill University, Montreal, QC, Canada.
Annick Bérard-GiassonDepartment of Anaesthesia, Division of Paediatric Anaesthesia, McGill University, Montreal, QC, Canada.
Frederic LamondeResearch Institute of McGill University, Montreal, QC, Canada.
Menglan PangDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Sam J DanielDepartments of Paediatric Surgery and Otolaryngology-Head and Neck Surgery, McGill University, Montreal, QC, Canada.
Karen A BrownDepartment of Anaesthesia, Division of Paediatric Anaesthesia, McGill University, Montreal, QC, Canada. Electronic address: karen.brown@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep-disordered breathing (oSDB) is pro-inflammatory and might modulate pain. We hypothesised that post-adenotonsillectomy pain and analgesic use would correlate with oSDB severity.

methodsWe conducted a prospective cohort study of children aged 2-12 yr undergoing adenotonsillectomy. Symptom severity of oSDB was assessed with the modified Snoring, Trouble Breathing, Un-Refreshed (mSTBUR) questionnaire. Parents recorded the Parents' Postoperative Pain Measure (PPPM) and analgesic medications for 14 postoperative days (PODs).

resultsComplete PPPM data (2480 scores) for 10 PODs were recorded for 124/245 (51%) patients. An additional 1539 PPPM scores were recorded in 121 patients; imputed values were derived for 941 missing PPPM scores. In this dataset (n=245), group-based trajectory models identified three trajectory groups for mild/brief (Trajectory1, n=108), moderate (Trajectory2, n=90), and severe/prolonged (Trajectory3, n=47) pain. Trajectories exhibited distinct PPPM scores on POD1. Children with higher preoperative mSTBUR scores were significantly less likely to be in the low or moderate pain trajectory groups compared with the severe pain group (odds ratio [OR], 0.52; 95% confidence interval [95% CI], 0.27-0.97; P=0.040 and OR, 0.58; 95% CI, 0.35-0.97; P=0.037). The association between mSTBUR and the PPPM scores was stronger for younger children. When compared with Trajectory1, children in Trajectory2 and Trajectory3 received more daily doses of analgesics (P=0.04) and had, respectively, four-fold and 11-fold higher odds for unscheduled revisits (OR, 3.5; 95% CI, 1.0-11.7; P=0.044 and 10.5; 95% CI, 3.1-35.7; P=0.0002).

conclusionsPost-adenotonsillectomy pain at home followed three distinct pain trajectories. Children with severe oSDB (higher mSTBUR scores) were more likely to have severe prolonged pain and to return more often to hospital. CLINICAL

trial registrationNCT03378830.

Indexed as

AdenoidectomyPostoperative PainSleep Apnea, ObstructiveTonsillectomyAnalgesicsChildChild, PreschoolCohort StudiesFemaleHumansMalePain MeasurementProspective StudiesSeverity of Illness IndexAnalgesicspaediatricspainsleep-disordered breathingSTBURtonsillectomy

Identifiers

PMID41314942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.