Evidence map›Paper›PMID 41314797›Full record

ArticleCancer reports (Hoboken, N.J.)2025

Development of Symptomatic Bone Marrow Metastasis After Complete Response to Immunochemotherapy in Squamous Cell Lung Carcinoma.

Akari Momose, Tomonobu Koizumi, Risa Takei, Yutaro Waki, Hajime Midorikawa, Nami Kitagawa, Fumihiro Kawakami, Maki Ohya, Hideaki Hamano

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akari MomoseDepartment of Medicine, Nagano Prefectural Kiso Hospital, Nagano, Japan.
Tomonobu KoizumiDepartment of Medicine, Nagano Prefectural Kiso Hospital, Nagano, Japan.ORCID 0000-0002-5182-0960
Risa TakeiDepartment of Medicine, Nagano Prefectural Kiso Hospital, Nagano, Japan.
Yutaro WakiDepartment of Medicine, Nagano Prefectural Kiso Hospital, Nagano, Japan.
Hajime MidorikawaDepartment of Medicine, Nagano Prefectural Kiso Hospital, Nagano, Japan.
Nami KitagawaDepartment of Medicine, Nagano Prefectural Kiso Hospital, Nagano, Japan.
Fumihiro KawakamiDepartment of Hematology and Medical Oncology, Shinshu University School of Medicine, Nagano, Japan.
Maki OhyaDepartment of Pathology, Shinshu University School of Medicine, Nagano, Japan.
Hideaki HamanoDepartment of Medicine, Nagano Prefectural Kiso Hospital, Nagano, Japan.ORCID 0009-0008-6531-7179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSymptomatic bone marrow metastasis in squamous cell lung cancer after achieving a complete response to immunochemotherapy has not been reported previously. CASE PRESENTATION: A 63-year-old Japanese man was referred to our hospital for further examination of an abnormal chest radiograph. Whole-body computed tomography revealed left hilar swelling and osteolytic lesions. Bronchoscopic examination led to a diagnosis of squamous cell lung carcinoma with multiple bone metastases. He was treated with carboplatin/Nab-paclitaxel and pembrolizumab, and achieved complete response as determined by positron emission tomography with fluorodeoxyglucose-computed tomography. Despite pembrolizumab maintenance therapy for 1 year, thrombocytopenia, anemia, and leukoerythroblastosis occurred. Bone marrow biopsy revealed squamous cell carcinoma cells within fibrotic tissue, confirming the diagnosis of symptomatic bone marrow metastases. The patient died 1 month after this diagnosis.

conclusionRecurrence presenting bone marrow metastasis should be considered in patients with squamous cell lung cancer, even achieving complete response to immunochemotherapy, particularly those with bone metastases.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBone Marrow NeoplasmsCarcinoma, Squamous CellLung NeoplasmsAlbuminsAntibodies, Monoclonal, HumanizedCarboplatinFatal OutcomeHumansMaleMiddle AgedPaclitaxelPositron Emission Tomography Computed Tomography130-nm albumin-bound paclitaxelAlbuminsAntibodies, Monoclonal, HumanizedCarboplatinPaclitaxelpembrolizumabbone metastasisimmunochemotherapyleukoerythroblastosisnon‐small cell lung cancerthrombocytopenia

Identifiers

PMID41314797
PMCPMC12662705

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.