Evidence map›Paper›PMID 41314773›Full record

ArticleMolecular pharmaceutics2026

Chemically Cross-Linked Nanocapsules from Terpolymers of Polyethylene Glycol-Polylactide with Cationic Pendent Groups for Pgp-siRNA and Doxorubicin Codelivery in Overcoming Multidrug Resistance in Breast Cancer.

Zheng-Ian Lin, Tzu-Hsien Tsai, Li-Hsien Wu, Chien-Hou Lu, Chih-Yuan Hsu, Haiqing Liang, Hsin-Yu Lin, Yi-Ping Fang, Wing-Cheung Law, Cheng-Hsi Chang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zheng-Ian LinPolymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Tzu-Hsien TsaiDivision of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan.
Li-Hsien WuDepartment of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Chien-Hou LuDepartment of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan.
Chih-Yuan HsuPolymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Haiqing LiangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.
Hsin-Yu LinPolymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Yi-Ping FangSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0001-8770-5289
Wing-Cheung LawDepartment of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, P. R. China.ORCID 0000-0003-3855-6170
Cheng-Hsi ChangDivision of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan.
Hau-En LiouDivision of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan.
Chengbin YangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.ORCID 0000-0001-9672-7412
Pei-Wen ChengDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital Kaohsiung, Kaohsiung 81362, Taiwan.
Che-Hsin LeeDepartment of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Chih-Kuang ChenPolymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.ORCID 0000-0002-7896-2424

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer remains one of the leading causes of mortality worldwide. Among current treatment strategies, chemotherapy continues to play a central role; however, its therapeutic efficacy is markedly compromised by the development of multidrug resistance (MDR) in cancer cells. To address this challenge, a new triblock copolymer, poly(ethylene glycol)-

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1Breast NeoplasmsDoxorubicinDrug Resistance, MultipleNanocapsulesPolyestersPolyethylene GlycolsRNA, Small InterferingCell Line, TumorDrug CarriersDrug Resistance, NeoplasmFemaleHumansMCF-7 CellsPolymersATP Binding Cassette Transporter, Subfamily B, Member 1DoxorubicinDrug CarriersNanocapsulesPolyestersPolyethylene Glycolspoly(lactide)PolymersRNA, Small Interferingcancerdrug/gene coloadingmultidrug resistancenanocapsulespolylactide

Identifiers

PMID41314773
PMCPMC12776577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.